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Thionization Method of Glycosyl Urea and Carbamide Sugars
Department of Medical-Biological Disciplines, Zhalal-Abad State University, Zhalal-Abad, Kyrgyzstan
Department of Medical-Biological Disciplines, Zhalal-Abad State University, Zhalal-Abad, Kyrgyzstan
Institute of Chemistry and Phytotechnology, National Academy of Sciences, Bishkek, Kyrgyzstan
International Medical Faculty, Osh State University, Jolon Mamytov Campus, Osh, Kyrgyzstan
Department of Medical-Biological Disciplines, Zhalal-Abad State University, Zhalal-Abad, Kyrgyzstan
Zhalal-Abad Scientific Center, Southern Branch of the National Academy of Sciences, Zhalal-Abad, Kyrgyzstan
- 1 Department of Medical-Biological Disciplines, Zhalal-Abad State University, Zhalal-Abad, Kyrgyzstan
- 2 Department of Medical-Biological Disciplines, Zhalal-Abad State University, Zhalal-Abad, Kyrgyzstan
- 3 Institute of Chemistry and Phytotechnology, National Academy of Sciences, Bishkek, Kyrgyzstan
- 4 International Medical Faculty, Osh State University, Jolon Mamytov Campus, Osh, Kyrgyzstan
- 5 Department of Medical-Biological Disciplines, Zhalal-Abad State University, Zhalal-Abad, Kyrgyzstan
- 6 Zhalal-Abad Scientific Center, Southern Branch of the National Academy of Sciences, Zhalal-Abad, Kyrgyzstan
International Journal of Organic Chemistry·Volume 10 (2020)·Pages 111–122·Published 16 September 2020·DOI10.4236/ijoc.2020.103008
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Abstract
This work is describing a thionization method for glycosyl urea and carbamide of sugars by using the Lawesson’s reagent. It is proposed the method based on the interaction of glycosyl urea and carbamide of sugars with the Lawessons reagent at a 1:1 ratio in the presence of a pyridine. As a result, sulfur-containing derivatives of sugar carbamides are obtained with the help of Lawesson’s reagent. Obtained experimental data are indicating the developed new method for thionization of sugar carbamides, which opens up broad possibilities for synthesis of various carbohydrate derivatives of thiourea. Significance of this work is that, thiourea derivatives are promising bactericidal, fungicidal and anti-inflammatory drugs. Therefore, the preparation of thiourea derivatives and the study of their properties remain topical tasks in the field of chemistry.
KeywordsGlycosyl UreaGlycosyl Thiourea SynthesisLawesson’s ReagentAnti-InflammatoryBactericidalFungicidal Properties
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