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Microwave Irradiated Palladium-Catalyzed Cascade Type Cross Coupling of Phenols and Halides for the Synthesis of Polyphenolic Ethers
Department of Chemistry, Tennessee State University, Nashville, TN, USA
Department of Chemistry, Tennessee State University, Nashville, TN, USA
- 1 Department of Chemistry, Tennessee State University, Nashville, TN, USA
- 2 Department of Chemistry, Tennessee State University, Nashville, TN, USA
International Journal of Organic Chemistry·Volume 10 (2020)·Pages 135–143·Published 25 November 2020·DOI10.4236/ijoc.2020.104010
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Abstract
A mild, cascade type methodology was developed for the synthesis of polyphenolic ethers by the palladium-catalyzed cross coupling of phenols and halo compounds under microwave heating. In most cases, reactions run in neat conditions and in some cases, IPA/water mixture, and 1,4-dioxane were employed as solvents to furnish the products. By applying this new method, we were able to synthesize and purify a good number of polyether compounds with complete spectral data.
KeywordsPolyphenolic EtherCross-CouplingCascade Type ReactionMicrowave Heating
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