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3-(Tetrazol-5-yl)-2-imino-coumarins Derivatives: Synthesis, Characterization, and Evaluation on Tumor Cell Lines
Laboratoire de Chimie Appliquée: Hétérocycles, Corps Gras et Polymères, Faculté des Sciences de Sfax, Université de Sfax, Sfax, Tunisie
Laboratoire de Chimie Appliquée: Hétérocycles, Corps Gras et Polymères, Faculté des Sciences de Sfax, Université de Sfax, Sfax, Tunisie
Chemistry Department, College of Science and Arts, Jouf University, Al Qurayyat, Al Jawf, KSA
Chemistry Department, College of Science and Arts, Jouf University, Al Qurayyat, Al Jawf, KSA
Institut des Sciences Chimiques de Rennes, ISCR UMR CNRS 6226, Campus Beaulieu, Université de Rennes 1, Bat. 10A, Rennes Cedex, France
ImPACcell Platform, SFR Biosit Bat. 8, Campus Villejean, Rennes Cedex, France
ImPACcell Platform, SFR Biosit Bat. 8, Campus Villejean, Rennes Cedex, France
Laboratoire de Chimie Appliquée: Hétérocycles, Corps Gras et Polymères, Faculté des Sciences de Sfax, Université de Sfax, Sfax, Tunisie
S2Wave Platform, ScanMAT UMS 2001 CNRS, Campus Beaulieu, Université de Rennes 1, Bat. 10A, Rennes Cedex, France
- 1 Laboratoire de Chimie Appliquée: Hétérocycles, Corps Gras et Polymères, Faculté des Sciences de Sfax, Université de Sfax, Sfax, Tunisie
- 2 Laboratoire de Chimie Appliquée: Hétérocycles, Corps Gras et Polymères, Faculté des Sciences de Sfax, Université de Sfax, Sfax, Tunisie
- 3 Chemistry Department, College of Science and Arts, Jouf University, Al Qurayyat, Al Jawf, KSA
- 4 Chemistry Department, College of Science and Arts, Jouf University, Al Qurayyat, Al Jawf, KSA
- 5 Institut des Sciences Chimiques de Rennes, ISCR UMR CNRS 6226, Campus Beaulieu, Université de Rennes 1, Bat. 10A, Rennes Cedex, France
- 6 ImPACcell Platform, SFR Biosit Bat. 8, Campus Villejean, Rennes Cedex, France
- 7 ImPACcell Platform, SFR Biosit Bat. 8, Campus Villejean, Rennes Cedex, France
- 8 Laboratoire de Chimie Appliquée: Hétérocycles, Corps Gras et Polymères, Faculté des Sciences de Sfax, Université de Sfax, Sfax, Tunisie
- 9 S2Wave Platform, ScanMAT UMS 2001 CNRS, Campus Beaulieu, Université de Rennes 1, Bat. 10A, Rennes Cedex, France
International Journal of Organic Chemistry·Volume 11 (2021)·Pages 24–34·Published 28 January 2021·DOI10.4236/ijoc.2021.111003
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Abstract
The first report of new 3-(tetrazol-5-yl)-2-iminocoumarin derivatives is described. The title compounds were prepared in two steps and were obtained in good yields (55-93%). They have been fully characterized by 1 H, 13 C NMR, FTIR, UV-Visible and HRMS. They were tested for their antiproliferative activities against six representative human tumor cell lines (Huh 7-D12, Caco2, MDA-MB231, HCT 116, PC3 and NCI-H727) and HaCat keratinocytes. Among them, compound 5e was active on HCT 116 (IC 50 15 μM).
Keywords2-IminocoumarinTetrazoleFluorescenceTumor Cell LinesHCT 116
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