Novel Tandem Three Consecutive Reactions: Aza-Wittig, Imine Condensation and Electrophilic Aromatic Substitution Strategy to Indolizine Synthesis — Oak Academic Publishing
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Novel Tandem Three Consecutive Reactions: Aza-Wittig, Imine Condensation and Electrophilic Aromatic Substitution Strategy to Indolizine Synthesis
Centro Conjunto de Investigación en Química Sustentable (CCIQS) UAEM-UNAM, Universidad Autónoma del Estado de México, Unidad San Cayetano, Toluca de Lerdo, México
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Departamento de Química Orgánica, Facultad de Química, Universidad Autónoma del Estado de México, Paseo Colón/Paseo Tollocan s/n, Toluca, Estado de México, México
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Centro Conjunto de Investigación en Química Sustentable (CCIQS) UAEM-UNAM, Universidad Autónoma del Estado de México, Unidad San Cayetano, Toluca de Lerdo, México
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Centro Conjunto de Investigación en Química Sustentable (CCIQS) UAEM-UNAM, Universidad Autónoma del Estado de México, Unidad San Cayetano, Toluca de Lerdo, México
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Department de Chimie et Biochimie, Université de Moncton, Moncton, Canadá
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Centro Conjunto de Investigación en Química Sustentable (CCIQS) UAEM-UNAM, Universidad Autónoma del Estado de México, Unidad San Cayetano, Toluca de Lerdo, México
1 Centro Conjunto de Investigación en Química Sustentable (CCIQS) UAEM-UNAM, Universidad Autónoma del Estado de México, Unidad San Cayetano, Toluca de Lerdo, México
2 Departamento de Química Orgánica, Facultad de Química, Universidad Autónoma del Estado de México, Paseo Colón/Paseo Tollocan s/n, Toluca, Estado de México, México
3 Centro Conjunto de Investigación en Química Sustentable (CCIQS) UAEM-UNAM, Universidad Autónoma del Estado de México, Unidad San Cayetano, Toluca de Lerdo, México
4 Centro Conjunto de Investigación en Química Sustentable (CCIQS) UAEM-UNAM, Universidad Autónoma del Estado de México, Unidad San Cayetano, Toluca de Lerdo, México
5 Department de Chimie et Biochimie, Université de Moncton, Moncton, Canadá
6 Centro Conjunto de Investigación en Química Sustentable (CCIQS) UAEM-UNAM, Universidad Autónoma del Estado de México, Unidad San Cayetano, Toluca de Lerdo, México
Reaction of ethyl (Z)-3-(heteroaryl/aryl)-2-((triphenyl- λ 5 -phosphaneylidene) amino) acrylates intermediates with 2,3-thiophenedicarboxaldehyde w as used in novel Tandem three consecutive reactions: aza-Wittig, imine condensation and electrophilic heteroaromatic cyclization to obtain a series of indolizines. A tentative mechanism of this reaction is proposed.
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