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Synthesis and Evaluation of Quinolino-Benzoxaboroles as Potential Antimicrobial Agents
Integrated Biosciences Graduate Program, University of Minnesota, Duluth, MN, USA
Integrated Biosciences Graduate Program, University of Minnesota, Duluth, MN, USA
Department of Biology, University of Washington, Seattle, WA, USA
Department of Chemistry and Biochemistry, University of Minnesota Duluth, Duluth, MN, USA
Integrated Biosciences Graduate Program, University of Minnesota, Duluth, MN, USA
- 1 Integrated Biosciences Graduate Program, University of Minnesota, Duluth, MN, USA
- 2 Integrated Biosciences Graduate Program, University of Minnesota, Duluth, MN, USA
- 3 Department of Biology, University of Washington, Seattle, WA, USA
- 4 Department of Chemistry and Biochemistry, University of Minnesota Duluth, Duluth, MN, USA
- 5 Integrated Biosciences Graduate Program, University of Minnesota, Duluth, MN, USA
International Journal of Organic Chemistry·Volume 12 (2022)·Pages 53–63·Published 19 April 2022·DOI10.4236/ijoc.2022.122005
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Abstract
Several quinolino-benzoxaborole derivatives have been prepared to start from aminobenzoxaboroles. These derivatives have been evaluated for their anti- cancer activity on human and murine cancer cell lines and based on their relative non-toxicity, these compounds were further evaluated for their antibacterial activity against E. coli , B. subtilis , and M. smegmatis . The synthesized compounds were also evaluated for antifungal activity in C. albicans and C. neoformans .
KeywordsBenzoxaborolesAminobenzoxaborolesQuinolino-BenzoxaborolesAnti-Microbial Agents
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