In this work, some new oxadiazole derivatives have been prepared, by reacting phenyl hydrazine and acetic anhydride together, which furnished 2,4- dimethyl-4-phenyloxadiazole. This product was reacted with a series of aromatic aldehydes, to obtain a series of oxadiazole derivatives. These derivatives were characterized by TLC, melting points, infrared red, proton nuclear m agnetic resonance, carbon thirteen nuclear magnetic resonance and mass spec troscopy. Finally, these synthetized derivatives were tested for antiproliferativ e activity by two different cell lines. MCF-7 (Breast cancer cell line) and HepG2 (Liver cancer cell line) were used to assess the antiproliferative activity of the prepared compounds.
KeywordsPhenyl HydrazineOxadiazoleAromatic AldehydesAcetic AnhydrideBenzylidene SynthesisCytotoxic AssayAnticancerHepG2 and MCF-7
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