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Pd-Catalyzed Unprecedented Cross-Coupling of Mixed Phenols and Halides for the Synthesis of Aromatic Ethers
Department of Chemistry, Tennessee State University, Nashville, TN, USA
Department of Chemistry, Tennessee State University, Nashville, TN, USA
Department of Chemistry, Tennessee State University, Nashville, TN, USA
- 1 Department of Chemistry, Tennessee State University, Nashville, TN, USA
- 2 Department of Chemistry, Tennessee State University, Nashville, TN, USA
- 3 Department of Chemistry, Tennessee State University, Nashville, TN, USA
International Journal of Organic Chemistry·Volume 12 (2022)·Pages 75–91·Published 19 April 2022·DOI10.4236/ijoc.2022.122007
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Abstract
Phenolic compounds present in medicinal and edible plants such as flavonoids, chalcones, coumarins, quinones, and phenolic acids. The antioxidant potential of phenolic compounds shows potent activities for cancer prevention and its treatment. From a green chemistry point of view, cascade (tandem) reac tions are ideal techniques in organic synthesis for building complex structures. Cascade techniques are sometimes observe d in coupling reactions under mild conditions with a tolerance of multifunctional groups. It will be interesting to find a cascade type reaction to synthesize polyphenolic ethers. This research project achieves a new cross-coupling method for establishing polyphenolic ethers from mixed phenols and halides in the presence of palladium catalyst in moderate to good yields.
KeywordsMicrowaveEthers from Mixed PhenolsCross-CouplingCascade Type Reac-tion
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