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Synthesis and Antitumor Activity of 3-[2-(4-Hydroxy-Phenyl)-Ethyl]-Benzo[<i>d</i>] Isoxazole-4,6-Diol
The First Affliated Hospital of Xi’an Medical University, Xi’an, China
- 1 The First Affliated Hospital of Xi’an Medical University, Xi’an, China
International Journal of Organic Chemistry·Volume 13 (2023)·Pages 1–6·Published 2 February 2023·DOI10.4236/ijoc.2023.131001
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Abstract
A new phloretin derivative 1 3-[2-(4-hydroxy-phenyl)-ethyl]-benzo[d] isoxazole-4,6-diol (yield 63%) was synthesized from phloretin by carbonyl nucleophilic addition condensation reaction. Its structure was characterized by 1H NMR, 13C NMR and HR-MS. The phloretin, compound 1, resveratrol and acetylated resveratrol were determined by comparing them with paclitaxel. Anti-tumor activity of alcohol on SPC-A1, EC109, A549, MCF-7 and MDA-MB-231 cell lines. Compound 1 showed better antitumor activity than docetaxel against A549 tumor cells.
Keywords3-[2-(4-Hydroxy-Phenyl)-Ethyl]-Benzo[<i>d</i>] Isoxazole-46-DiolSynthesisAntitumor Activity
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