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A New Process of Synthesizing Anandamide Derivatives from Arachidonic Acid in the Presence of Boron Catalyst
Department of Chemistry, Tennessee State University, Nashville, TN, USA
Department of Chemistry, Tennessee State University, Nashville, TN, USA
- 1 Department of Chemistry, Tennessee State University, Nashville, TN, USA
- 2 Department of Chemistry, Tennessee State University, Nashville, TN, USA
International Journal of Organic Chemistry·Volume 14 (2024)·Pages 128–134·Published 12 October 2024·DOI10.4236/ijoc.2024.144008
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Abstract
Anandamide is part of the cannabinoid group and functions as a neurotransmitter. Anandamide plays a role in depression, pain, appetite, memory, and fertility. Since it is well documented that anandamide analog behaves as probes of the cannabinoid receptor, it is of great interest to find a new method of making new series of anandamide derivatives. Dennis Hall and his group recently reported a direct amidation process of carboxylic acid by ortho-iodo boronic acid. Using ortho-iodo boronic acid as a catalyst, we explore the amidation of arachidonic acid under microwave heating and synthesize anandamide derivatives in high yields.
KeywordsAnandamideCross-CouplingMicrowaveAlcohol Amines
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