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Anti-Salmonellal Schiff Bases from Vanillin: Synthesis and Structure Elucidation
Department of Chemistry, Faculty of Science, University of Buea, Buea, Cameroon
Department of Chemistry, Faculty of Science, University of Buea, Buea, Cameroon
Department of Chemistry, Faculty of Science, University of Buea, Buea, Cameroon
Department of Biochemistry and Molecular Biology, Faculty of Science, University of Buea, Buea, South West Region, Cameroon
Department of Biochemistry and Molecular Biology, Faculty of Science, University of Buea, Buea, South West Region, Cameroon
Department of Chemistry, Faculty of Science, University of Buea, Buea, Cameroon
Center for Advanced Materials Characterization in Oregon, University of Oregon, 1443 E, 13 th AVE, Eugene OR 97403, USA
Department of Chemistry, Faculty of Science, University of Buea, Buea, Cameroon
Department of Medical Laboratory Sciences, Faculty of Health Sciences, University of Buea, Buea, South West Region, Cameroon
- 1 Department of Chemistry, Faculty of Science, University of Buea, Buea, Cameroon
- 2 Department of Chemistry, Faculty of Science, University of Buea, Buea, Cameroon
- 3 Department of Chemistry, Faculty of Science, University of Buea, Buea, Cameroon
- 4 Department of Biochemistry and Molecular Biology, Faculty of Science, University of Buea, Buea, South West Region, Cameroon
- 5 Department of Biochemistry and Molecular Biology, Faculty of Science, University of Buea, Buea, South West Region, Cameroon
- 6 Department of Chemistry, Faculty of Science, University of Buea, Buea, Cameroon
- 7 Center for Advanced Materials Characterization in Oregon, University of Oregon, 1443 E, 13 th AVE, Eugene OR 97403, USA
- 8 Department of Chemistry, Faculty of Science, University of Buea, Buea, Cameroon
- 9 Department of Medical Laboratory Sciences, Faculty of Health Sciences, University of Buea, Buea, South West Region, Cameroon
International Journal of Organic Chemistry·Volume 15 (2025)·Pages 21–27·Published 5 August 2025·DOI10.4236/ijoc.2025.153003
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Abstract
A series of vanillin substituted Schiff bases namely; 2-methoxy-4-(pyridine-3-yl-hydrazonomethyl)-phenol, NT 1 (1), (4-hydroxy-3-methoxybenzylidene) isonicotinohydrazide, NT 2 (2), 4-[(2,4-dinitrophenyl) hydrazonomethyl]-2-methoxyphenol, NT 3 (3), 2-methoxy-4-phenyliminomethyl-phenol, NT 4 (4) were synthesized using vanillin and four aromatic amines: nicotinic acid hydrazide, 2,4-dinitrophenylhydrazine, isoniazid and aniline and their anti-salmonellal activity examined and reported in this work for the first time. The synthesized compounds were characterized by Nuclear Magnetic Resonance (NMR), Fourier Transformer-Infrared (FT-IR) and melting points. The anti-salmonellal activity of the synthesized compounds was studied in comparison with their reactants (amines and vanillin) using the disc diffusion and micro dilution method using 14 isolates of Salmonella typhi. The activity of compounds was consistent in both assays. The compounds showed overall relatively low in vitro bacteriostatic activity.
KeywordsVanillinAnti-SalmonellalDisc DiffusionMicro-DillutionSchiff Base
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