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A Remarkable Regioselective C3-Allylation of Indoles Using Potassium Allyltrifluoroborate under Palladium Catalysis
Department of Chemistry, Tennessee State University, Nashville, USA
Department of Chemistry, Tennessee State University, Nashville, USA
Department of Chemistry, Tennessee State University, Nashville, USA
- 1 Department of Chemistry, Tennessee State University, Nashville, USA
- 2 Department of Chemistry, Tennessee State University, Nashville, USA
- 3 Department of Chemistry, Tennessee State University, Nashville, USA
International Journal of Organic Chemistry·Volume 16 (2026)·Pages 1–6·Published 27 March 2026·DOI10.4236/ijoc.2026.161001
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Abstract
We report a new and efficient regioselective C3 allylation of indoles using potassium allyltrifluoroborate under PdCl 2 (dtbpf) catalysis and microwave assisted conditions. The method offers operational simplicity, high regioselectivity, good to excellent yields, and broad substrate compatibility. This study establishes potassium allyltrifluoroborate as a practical allylating reagent for indole functionalization and expands its applicability in synthetic organic chemistry.
KeywordsIndole C3-AllylationRegioselective Functionalization Potassium AllyltrifluoroboratePalladium CatalysisPdCl 2 (dtbpf) Catalyst
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