A series of pyrido[2,3- d ]pyrimidines derivatives have been prepared by one-pot three-component reaction of 4(6)-aminouracil, malononitrile and aromatic aldehydes. This efficient synthesis was done under microwave irradiation conditions (method A) and also using catalytic amount of diammonium hydrogen phosphate [(NH 4 ) 2 HPO 4 ] (DAHP) in aqueous media (method B). This procedure has the advantages of good yields, easy work-up, and benign environmentally friendly character. Reaction could proceed via domino Knoevenagel-Michael-cyclization reactions.
KeywordsDiammonium Hydrogen Phosphate (DAHP)Microwave Irradiation (MWI)Water in Organic SynthesisPyrido[23-<i>d</i>]pyrimidine
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