Highly Efficient Synthesis of Novel Fluorine Bearing Quinoline-4-carboxylic Acid and the Related Compounds as Amylolytic Agents — Oak Academic Publishing
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Highly Efficient Synthesis of Novel Fluorine Bearing Quinoline-4-carboxylic Acid and the Related Compounds as Amylolytic Agents
Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
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Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
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Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
1 Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
2 Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
3 Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
Highly efficient syntheses of novel fluorine bearing quinoline-4-carboxylic acids and the related compounds had been achieved from cyclocondensation of 2-amino-5-fluorophenyl glyoxylic acid 1 with benzoyle asetanilides 2 in boiling DMF, to give the target 3. Decarboxylation of 3 produced 6-fluoro-2-phenyl-3-(substituted amino)-keto-quinolines 4, while that reaction underwent refluxing, afforded 7-fluoro-1-(aryl)-3-phenyl-pyrrolo[3,4-c] quinoline-2,9-diones 5. Structure of the products has been established from their elemental and spectral analysis. All targets exhibited a high to moderate activity against some Aspergillus fungi as amylolytic agents.
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