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Designing and Synthesis of New Fluorine Substituted Pyrimidine-Thion-5-Carbonitriles and the Related Derivatives as Photochemical Probe Agents for Inhibition of Vitiligo Disease
Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
- 1 Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
- 2 Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
- 3 Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
- 4 Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
International Journal of Organic Chemistry·Volume 02 (2012)·Pages 311–320·Published 3 October 2012·DOI10.4236/ijoc.2012.223043
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Abstract
A new biocidal agents fluorine substituted-3-thioxopyrimidine-5-carbonitriles ( 2-9 ) and/or the related fluorine substi- tuted pyrimido ( 4,5-d ) pyrimidines ( 10-14 ) were synthesized by the cycloaddition of fluorinated β- arylidine malo- nonitriles (1a-c) followed by a nucleophilic attack against α,β-bifunctional reagents in different conditions. Structures of the fluorine targets were characterized by their elemental analysis and spectral data (UV, IR, 1 H NMR, 13 C NMR and mass measurements) and further evaluated as photochemical probe for inhibition of Vitiligo, it was found that compounds 5, 9, 11 and 12 exhibited high potency over the investigated compounds.
KeywordsSynthesisFluoropyrimidinesPhotochemical Probes
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