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The Reaction of Cyanoacetylhdrazine with Furan-2-Aldehyde: Novel Synthesis of Thiophene, Azole, Azine and Coumarin Derivatives and Their Antitumor Evaluation
National Organization for Drug Control & Research, Cairo, Egypt
Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt
Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt
National Organization for Drug Control & Research, Cairo, Egypt
- 1 National Organization for Drug Control & Research, Cairo, Egypt
- 2 Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt
- 3 Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt
- 4 National Organization for Drug Control & Research, Cairo, Egypt
International Journal of Organic Chemistry·Volume 02 (2012)·Pages 321–331·Published 27 December 2012·DOI10.4236/ijoc.2012.24044
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Abstract
The reaction of cyanoacetylhydrazine 1 with furan-2-aldehyde 2 gives the hydrazide-hydrazone derivative 3 . The latter compound undergoes a series of heterocyclization reactions to give new heterocyclic compounds. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) were recorded. Some of the synthesized compounds show high inhibitory effects.
KeywordsAcetylhydrazineHydrazide-HydrazoneThiopheneThiazolePyridineCoumarinAntitumor
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