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Synthesis and <i>in Vitro</i> Cytotoxic Activity of Novel Pyrazole-3,4-dicarboxylates
Laboratoire de Chimie Organique et Analytique, Faculté des Sciences et Techniques, Université Sultan Moulay Slimane, Béni-Mellal,Morocco
Laboratoire de Chimie Organique et Analytique, Faculté des Sciences et Techniques, Université Sultan Moulay Slimane, Béni-Mellal,Morocco
Laboratoire de Chimie Organique et Analytique, Faculté des Sciences et Techniques, Université Sultan Moulay Slimane, Béni-Mellal,Morocco
Laboratoire de Chimie Organique et Analytique, Faculté des Sciences et Techniques, Université Sultan Moulay Slimane, Béni-Mellal,Morocco
Laboratoire de Chimie Organique et Analytique, Faculté des Sciences et Techniques, Université Sultan Moulay Slimane, Béni-Mellal,Morocco
- 1 Laboratoire de Chimie Organique et Analytique, Faculté des Sciences et Techniques, Université Sultan Moulay Slimane, Béni-Mellal,Morocco
- 2 Laboratoire de Chimie Organique et Analytique, Faculté des Sciences et Techniques, Université Sultan Moulay Slimane, Béni-Mellal,Morocco
- 3 Laboratoire de Chimie Organique et Analytique, Faculté des Sciences et Techniques, Université Sultan Moulay Slimane, Béni-Mellal,Morocco
- 4 Laboratoire de Chimie Organique et Analytique, Faculté des Sciences et Techniques, Université Sultan Moulay Slimane, Béni-Mellal,Morocco
- 5 Laboratoire de Chimie Organique et Analytique, Faculté des Sciences et Techniques, Université Sultan Moulay Slimane, Béni-Mellal,Morocco
International Journal of Organic Chemistry·Volume 03 (2013)·Pages 37–41·Published 5 February 2013·DOI10.4236/ijoc.2013.31003
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Abstract
N -Aryl- C -ethoxycarbonylnitrile imines ( 3a-g ) react with ethyl cyanoacetate 1 in 1,3-dipolar cycloaddition to yield novel pyrazole-3,4-dicarboxylates ( 4a-g ) in moderate yields. The reaction of pyrazole-3,4-dicarboxylates ( 4a , d ) with hydrazine afforded pyrazolo[4,3-d]pyridazine-4,7-diones ( 5a , d ) in good yields. All compounds were fully characterized by spectroscopic methods. Some of the newly synthesized compounds were evaluated for their cytotoxic activity against murine P815 mastocytoma cell line.
KeywordsNitrile IminesCycloadditionPyrazolesCytotoxic Activity
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