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Design, Synthesis and Inhibitory Properties against Coxsackie B3/B6 of Some Novel Triazole Derivatives
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Zhejiang Medicine Co. Ltd., Xinchang Pharmaceutical Factory, Xinchang, China
- 1 School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China
- 2 School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China
- 3 School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China
- 4 School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China
- 5 School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China
- 6 Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
- 7 Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
- 8 Zhejiang Medicine Co. Ltd., Xinchang Pharmaceutical Factory, Xinchang, China
International Journal of Organic Chemistry·Volume 03 (2013)·Pages 41–46·Published 29 April 2013·DOI10.4236/ijoc.2013.31A005
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Abstract
A series of 1,2,4-triazole derivatives were synthesized, and their abilities to inhibit the in vitro replication of Coxsackie B3/B6 were evaluated. Among the 1,2,4-triazole derivatives, compound 3 g displayed potent activity, with a high antiviral potency (IC 50 = 1.71 μM (against CVB3), 1.43 μM (against CVB6)). The structures of all the new synthesized compounds were confirmed by 1 H-NMR spectra, mass spectra and elemental analyses.
Keywords124-TriazoleAnti-EnterovirusCoxsackie B Viruses
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