Aldols from aliphatic aldehydes had been synthesized enantioselectively using Singh’s catalyst. Self and crossed aldol reactions with several linear aldehydes were performed.
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L. Song, X. Chen, S. Zhang, H. Zhang, P. Li, W. Duan and W. Wang, “An Organocatalytic Approach to the Construction of Chiral Oxazolidinone Rings and Application in the Synthesis of Antibiotic Linezolid and Its Analogues,” Organic Letters, Vol. 10, No. 23, 2008, pp. 5489-5492. doi:10.1021/ol802333n
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S. Sulzer-Mossé and A. Alexakis, “Chiral Amines as Organocatalysts for Asymmetric Conjugate Addition to Nitroolefins and Vinyl Sulfones via Enamine Activation,” Chemical Communications, No. 30, 2007, pp. 3123-3135.
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