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New Method of Palladium Metal Trapping through Resins in Antiviral Drug: Valacyclovir HCl
Research and Development, Integrated Product Development, Innovation Plaza, Dr. Reddy’s Laboratories Ltd., Bachupally, Quthubullapur, India
Dr. MACS Bio-Pharma Pvt. Ltd., Western Hills, Kukatpally, Hyderabad, India
Research and Development, Integrated Product Development, Innovation Plaza, Dr. Reddy’s Laboratories Ltd., Bachupally, Quthubullapur, India
Research and Development, Integrated Product Development, Innovation Plaza, Dr. Reddy’s Laboratories Ltd., Bachupally, Quthubullapur, India
Research and Development, Integrated Product Development, Innovation Plaza, Dr. Reddy’s Laboratories Ltd., Bachupally, Quthubullapur, India
Department of Chemistry, Institute of Science and Technology, J. N. T. University, Kukatpally, Hyderabad, India
Research and Development, Integrated Product Development, Innovation Plaza, Dr. Reddy’s Laboratories Ltd., Bachupally, Quthubullapur, India
- 1 Research and Development, Integrated Product Development, Innovation Plaza, Dr. Reddy’s Laboratories Ltd., Bachupally, Quthubullapur, India
- 2 Dr. MACS Bio-Pharma Pvt. Ltd., Western Hills, Kukatpally, Hyderabad, India
- 3 Research and Development, Integrated Product Development, Innovation Plaza, Dr. Reddy’s Laboratories Ltd., Bachupally, Quthubullapur, India
- 4 Research and Development, Integrated Product Development, Innovation Plaza, Dr. Reddy’s Laboratories Ltd., Bachupally, Quthubullapur, India
- 5 Research and Development, Integrated Product Development, Innovation Plaza, Dr. Reddy’s Laboratories Ltd., Bachupally, Quthubullapur, India
- 6 Department of Chemistry, Institute of Science and Technology, J. N. T. University, Kukatpally, Hyderabad, India
- 7 Research and Development, Integrated Product Development, Innovation Plaza, Dr. Reddy’s Laboratories Ltd., Bachupally, Quthubullapur, India
International Journal of Organic Chemistry·Volume 03 (2013)·Pages 251–255·Published 4 December 2013·DOI10.4236/ijoc.2013.34036
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Abstract
This process describes a novel technique for effective trapping of “Pd” metal through resins during the process development of L-valine, 2-[(2-amino-1,6-dihydro-6-oxo-9 H -purin-9-yl) methoxy] ethyl ester, and mono hydrochloride known as a Valacyclovir hydrochloride ( 1 ). This technique is suitable for large-scale production of 1 and it is described here Pd metal trapping by using different resins.
KeywordsValacyclovir HydrochlorideAntiviral Drug<i>N</i>-Phthalimide-L-Valine EsterMonomethylamineCommercially Scalable ProcessLess Cycle Time
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