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Highly Efficient, One Pot Synthesis and Oxidation of Hantsch 1,4-Dihydropyridines Mediated by Iodobenzene Diacetate (III) Using Conventional Heating, Ultrasonic and Microwave Irradiation
Mewat Engineering College (WAKF), Nuh, India
Department of chemistry, Kurukshetra University, Kurukshetra, India
- 1 Mewat Engineering College (WAKF), Nuh, India
- 2 Department of chemistry, Kurukshetra University, Kurukshetra, India
International Journal of Organic Chemistry·Volume 04 (2014)·Pages 174–181·Published 25 August 2014·DOI10.4236/ijoc.2014.43019
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Abstract
A mild, general, convenient, and efficient one-pot synthesis of 4-arylpyridines (4) is described using conventional heating, ultrasound and microwave irradiation. Aryl aldehydes (2) were efficiently condensed with ethylacetoacetate (1) and ammonium acetate in acetonitrile to give dihydropyridine intermediates (4). The latter underwent a smooth Iodobenzene Diacetate (III) mediated aromatization reaction in the same pot to afford 4-arylpyridines (4) in good to excellent yields.
KeywordsDihydropyridinesIodobenzene DiacetateUltrasonicMicrowaveOne-PotFormylpyrazoles
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