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A Facile and Inexpensive Synthesis of 6-Ethynylbipyridine
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International Journal of Organic Chemistry·Volume 01 (2011)·Pages 33–36·Published 5 May 2011·DOI10.4236/ijoc.2011.12006
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Abstract
An inexpensive synthesis of 6-ethynylbipyridine has been accomplished using Sonogashira coupling of 2-bromo-6-iodopyridine with 2-methyl-3-butyn-2-ol. Subsequent Stille coupling with 2-(trimethylstannanyl) pyridine and hydrolysis provided the target compound in an overall high yield.
Keywords6-Ethynylbipyridine2-Bromo-6-Iodopyridine2-Methyl-3-Butyne-2-OlPalladium Coupling
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