Synthesis of New Fluorinated 1,2,4-Triazino [3,4-b][1,3,4]thiadiazolones as Antiviral Probes-Part II-Reactivities of Fluorinated 3-Aminophenyl-1,2,4-triazinothiadiazolone — Oak Academic Publishing
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Synthesis of New Fluorinated 1,2,4-Triazino [3,4-b][1,3,4]thiadiazolones as Antiviral Probes-Part II-Reactivities of Fluorinated 3-Aminophenyl-1,2,4-triazinothiadiazolone
Chemistry Department, Faculty of Science, King Abdul Aziz University, Jeddah, Kingdom of Saudi Arabia
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Chemistry Department, Faculty of Science, King Abdul Aziz University, Jeddah, Kingdom of Saudi Arabia
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Chemistry Department, Faculty of Science, King Abdul Aziz University, Jeddah, Kingdom of Saudi Arabia
1 Chemistry Department, Faculty of Science, King Abdul Aziz University, Jeddah, Kingdom of Saudi Arabia
2 Chemistry Department, Faculty of Science, King Abdul Aziz University, Jeddah, Kingdom of Saudi Arabia
3 Chemistry Department, Faculty of Science, King Abdul Aziz University, Jeddah, Kingdom of Saudi Arabia
Some new fluorinated 3-N-acyl/3-N-alkylaminophenyl-1,2,4-triazino[3,4-b][1,3,4]thiadiazolones (2-12) have been obtained from treatment of 2-(4'-fluorophenyl)-6-(2'-amino-5'-fluorophenyl)-1,2,4-triazino[3,4-b][1,3,4]thiadiazol-4-one(1) with active functional oxygen, sulfur and halogen compounds in different conditions. Former structures of the products have been characterized from elemental and spectral data (UV, IR, NMR and Mass). The new products were evaluated as potential anthelmintic drugs.
Al-Harbi, A.S., Abdel-Rahman, R.M. and Asiri, A.M. (2014) Synthesis of Some New Fluorine Substituted Thiobarbituric Acid Derivatives as Anti-HIV1 and Cyclin-Dependent Kinase 2(CDK2) for Cell Tumor Division—Part II. International Journal of Organic Chemistry, 4, 142-153. http://dx.doi.org/10.4236/ijoc.2014.42016
Makki, M.S.T., Ab-del-Rahman, R.M. and Khan K.A. (2014) Fluorine Substituted 1,2,4-Triazinones as Potential Anti-HIV-1 and CDK2 Inhicitors. Journal of Chemistry, 2014, Article ID: 430573.
Makki, M.S.T., Abdel-Rahman, R.M., Faidallah, H.M. and Khan K.A. (2013) Synthesis of New Fluorine Substituted Heterocyclic Nitrogen Systems Derived from p-Aminosalicyclic Acid as Anti-Mycobacterial Agents. Journal of Chemistry, 2013, Article ID: 819462.
Makki, M.S.T., Abdel-Rahman, R.M., Faidallah, H.M. and Khan, K.A. (2013) Synthesis of Substituted Thioureas and Their Sulfur Heterocyclic Systems of p-Aminosalicylic Acid as Anti-Mycobacterial Agents. Journal of Chemistry, 2013, Article ID: 862463.
Abdel-Rahman, R.M. and Ali, T.S. (2013) Synthesis and Biological Evaluation of Some New Polyfluorinated 4-Thiazolidinone and α-Aminophosphonic Acid Derivatives. Monatshefte für Chemie, 144, 1243-1252. http://dx.doi.org/10.1007/s00706-013-0934-6
Makki, M.S.T., Bakhotmah, D.A., Abdel-Rahman, R.M. and Elshahawy, M.S. (2012) Designing and Synthesis of New Fluorine Substituted Pyrimidine-Thion-5-Carbonitriels and the Related Derivatives as Photochemical Probe Agents for Inhibition of Vitiligo Diseases. International Journal of Organic Chemistry, 2, 311-320.
Makki, M.S.T., Bakhotmah, D.A. and Abdel-Rahman, R.M. (2012) Highly Efficient Synthesis of Novel Fluorine Bearing Quinolone-4-carboxylic Acid the Related Compounds as Amylolytic Agents. International Journal of Organic Chemistry, 2, 49-55. http://dx.doi.org/10.4236/ijoc.2012.21009
Abdel-Rahman, R.M., Makki, M.S.T. and Bawazir, W.A. (2011) Synthesis of Some More Fluorine Heterocyclic Nitrogen Systems Derived from Sulfa Drugs as Photochemical Probe Agents for Inhibition of Vitiligo Disease—Part I. E-Journal of Chemistry, 8, 405-414. http://dx.doi.org/10.1155/2011/586063
Abdel-Rahman, R.M., Makki, M.S.T. and Bawazir, W.A. (2010) Synthesis of Some More Fluorine Heterocyclic Nitrogen Systems Derived from Sulfa Drugs as Photochemical Probe Agents for Inhibition of Vitiligo Disease—Part II. E-Journal of Chemistry, 7, S93-S102.
Abdel-Rahman, R.M. (2001) Chemistry of Uncondensed 1,2,4-Triazines, Part IV—Synthesis and Chemistry of Bioactive 3-Amino-1,2,4-triazines and Related Compounds. Pharmacies, 56, 275-286.
Shawali, A.S, (2014) 1,3,4-Thiadiazoles of Pharmalogical Interest: Resent Trends in Their Synthesis via Tandem 1,3- Dipolar-Cycloaddition: Review. Journal of Advanced Research, 5, 1-17. http://dx.doi.org/10.1016/j.jare.2013.01.004
Kushwaha, N., Kushwaha, S.K.S. and Rai, A.K. (2011) Biological Activities of Thiadiazole Derivatives. International Journal of ChemTech Research, 4, 517-531.
Abdel-Rahman, R.M., Makki, M.S.T., Ali, T.S. and Ibrahim, M.A. (2012) 1,2,4-Triazine Chemistry Part III-Synthesis Strategies to Functionalized Brideghead Nitrogen Hetero Annulated 1,2,4-Triazine Systems and Their Region Specific and Pharmacological Properties. Current Organic Synthesis, 9, 1-25.
Abdel-Rahman, R.M., Makki, M.S.T., Ali, T.S. and Ibrahim, M.A. (2010) 1,2,4-Triazine Chemistry Part I: Orientation of Cyclization Reaction of Functionalized 1,2,4-Triazine Derivatives. European Journal of Chemistr, 1, 236-245. http://dx.doi.org/10.5155/eurjchem.1.3.236-245.54
Abdel-Rahman, R.M., Makki, M.S.T., Ali, T.S. and Ibrahim, M.A. (2014) 1,2,4-Triazine Chemistry Part IV: Synthesis and Chemical Behavior of 3-Functionalized-5,6-Diphenyl-1,2,4-Triazines towards Some Nucleophilic and Electrophilic Reagents. Journal of Hetero-cyclic Chemistry, ID JHET, 12-0734. http://dx.doi.org/10.1002/jhet.2014
El-Gendy, Z., Morsy, J.M., Allimony, H.A., Abdel-Monem, W.R. and Abdel-Rahman, R.M. (2001) Synthesis of Heterobicyclic Nitrogen Systems Bearing the 1,2,4-Triazine Moiety as Anti-HIV and Anticancer Drugs, Part III. Pharmazie, 56, 376-383.
Makki, M.S.T., Ab-del-Rahman, R.M. and Abu-Ali, O.A.(2015) Synthesis of Some More New Fluorinated 1,2,4-Triazino[3,4-b][1,3,4] Thiadiazolones and Their Molluscicidal Against Selective Snails—Part I. Journal of Chemistry and Chemical Engineering, 9, 162-175.
Abdel-Rahman, R.M. (1991) Synthesis and Anti-Human Immune Virus Activity of Some New Fluorine Con-taining Substituted 3-Thioxo-1,2,4-Triazin-5-Ones. Farmaco, 46, 379-389.
Abdel-Rahman, R.M. (1992) Synthesis of New Fluorine Bearing Trisubstituted 3-Thioxo-1,2,4-Triazin-5-Ons as Potential Anticancer Agents. Farmaco, 47, 319-326.
Al-Romazian, A.N., Makki, M.S.T. and Abdel-Rahman, R.M. (2014) Synthesis of New Fluorine/Phosphorus Substituted 6-(2’-Aminophenyl)-3-Thioxo-1,2,4-5(2H,4H)One and Their Related Alkylated Systems as Molluscicidal Agent as against the Snails Responsible for Bilharziiasis Diseases. International Journal of Organic Chemistry, 4, 154-168. http://dx.doi.org/10.4236/ijoc.2014.42017
Breuer, E. (1996) The Chemistry of Organophosphorus Compounds. John Wiley and Sons, NewYork.
Blakley, B., Broussea, U., Fournier, M. and Voccia, A.I. (1999) Immunotoxicity of Pesticides: A Review. Toxicology and Industral Health, 15, 119-132. http://dx.doi.org/10.1177/074823379901500110
Ibrahim, M.A., Abdel-Rahman, R.M., Abdel-Halim, A.M., Ibracim, S.S. and Allimony, H.A., (2008) Synthesis and Antifungal Activity of Novel Polyheterocyclic Compounds Containing 1,2,4-Triazine Moiety. Archive for Organic Chemistry, 2008, 202-215. http://dx.doi.org/10.3998/ark.5550190.0009.g19
Abdel-Rahman, R.M. and Islam, E.I. (1993) Synthesis and Reactions of Acetonitrile Dervatives Bearing a 5,6-Diphenyl-1,2,4-Tryazin-3-yl Moiety. Indian Journal of Chemistry, 32, 526-529.
Al-Harbi, A.S., Abdel-rahman, R.M. and Asiri, A.M. (2015) Synthesis of Some New Fluorine Substituted Thiobarbituric Acid Derivatives as Anti HIV-1 and Cyclin-Dependent Kinase 2(CDK2) for Cell Tumor Division-Part I. European Journal of Chemistry, 6, 63-70. http://dx.doi.org/10.5155/eurjchem.6.1.63-70.1147
Steward, J.S. (1955) Anthelmintic Studies: II. A Double Entero-Nemacidal Anthelmintic Test Covering a Wide Range of Activities. Parasitology, 45, 242-254. http://Dx.Doi.Org/10.1017/S003118200002761x
Stadden, O.P. (1963) Experimental Chemotherapy. Academic Press, New York.