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Palladium/Imadazolium Salt Mediated Cyclisations for the Synthesis of Heterocyclic Compounds
Centre for Drug Design and Development, Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
Centre for Biomolecular Design and Drug Development, The Chemistry Laboratory, CPES, University of Sussex, Brighton, UK
Department of Chemistry, University College London, London, UK
- 1 Centre for Drug Design and Development, Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
- 2 Centre for Biomolecular Design and Drug Development, The Chemistry Laboratory, CPES, University of Sussex, Brighton, UK
- 3 Department of Chemistry, University College London, London, UK
International Journal of Organic Chemistry·Volume 05 (2015)·Pages 223–231·Published 24 November 2015·DOI10.4236/ijoc.2015.54022
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Abstract
The use of intramolecular reactions involving palladium/imidazolium salts to synthesize hetero-cyclic compounds is described. Reactivity of phenyl, ethyl and methyl substituents leading to isolation of various isomeric products is also illustrated. Rearrangement of phenyl intermediates to furnish benzoxazoles is also mentioned.
Keywords<i>N</i>-Heterocyclic CarbenesHeterocyclic SystemsImidazolium SaltIntramolecular CyclicsationsPhosphine Ligands
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