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Synthesis, Molecular Structure and Anti-Onchocercal Studies of 1-(Phthalazin-1(2H)-one)[(Pyridin-2-yl)ethylidene]hydrazone
Department of Chemistry, University of Buea, Buea, Cameroon
Department of Chemistry, University of Buea, Buea, Cameroon
Department of Biomedical Sciences, University of Bamenda, Bambili, Cameroon
Department of Chemistry, University of Buea, Buea, Cameroon
- 1 Department of Chemistry, University of Buea, Buea, Cameroon
- 2 Department of Chemistry, University of Buea, Buea, Cameroon
- 3 Department of Biomedical Sciences, University of Bamenda, Bambili, Cameroon
- 4 Department of Chemistry, University of Buea, Buea, Cameroon
International Journal of Organic Chemistry·Volume 06 (2016)·Pages 77–84·Published 4 March 2016·DOI10.4236/ijoc.2016.61008
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Abstract
The novel ligand, 1-(phthalazin-1(2H)-one)[(pyridin-2-yl)ethylidene]hydrazone,(APN), derived from the antihypertensive drug, hydralazine hydrochloride, was synthesized and characterized by spectroscopic methods (IR, 1H NMR). The X-ray crystallographic data indicates that APN has an exocyclic C=N bond on the hydralazine moiety. APN revealed significant anti-onchocercal activity with IC50 values of 0.3125 μg/mL on microfilaria and 10 μg/mL on adult worms compared to the standard drug, ivermectin.
KeywordsHydralazine HydrochlorideSchiff BasesAnti-Onchocercal Activity
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