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Microwave Application and Anhydrous Cu(OAc)<sub>2</sub> Mediated O-Arylation of Aliphatic Amino Alcohols
Department of Chemistry, Tennessee State University, Nashville, TN, USA
Department of Chemistry, Tennessee State University, Nashville, TN, USA
Department of Chemistry, Tennessee State University, Nashville, TN, USA
- 1 Department of Chemistry, Tennessee State University, Nashville, TN, USA
- 2 Department of Chemistry, Tennessee State University, Nashville, TN, USA
- 3 Department of Chemistry, Tennessee State University, Nashville, TN, USA
International Journal of Organic Chemistry·Volume 06 (2016)·Pages 100–106·Published 19 May 2016·DOI10.4236/ijoc.2016.62011
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Abstract
Anhydrous Cu(OAc) 2 mediated efficient protocol has been developed in the area of C-O coupling from potassium aryltrifluoroborates and aliphatic amino alcohols such as β -hydroxy, γ-hydroxy, and δ -hydroxy amines. The scope of this transformation focuses on direct O-arylation and O-styrylation. The reaction vial loaded with reactants under argon atmosphere is microwaved at 140°C for 30 min to furnish the corresponding cross-coupling product, amino ethers, in good yields.
KeywordsHydroxylamineAmino EtherO-ArylationO-StyrylationMicrowave
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