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Semi-Automated Synthesis of [F-18]FBAM, a Thiol Reactive Prosthetic Group, Using Continuous Flow Chemistry
Departments of Chemistry and Radiology, University of Tennessee, Knoxville, Tennessee, USA
Departments of Chemistry and Radiology, University of Tennessee, Knoxville, Tennessee, USA
Advion Biosystems, Ithaca, NY, USA
Departments of Chemistry and Radiology, University of Tennessee, Knoxville, Tennessee, USA
- 1 Departments of Chemistry and Radiology, University of Tennessee, Knoxville, Tennessee, USA
- 2 Departments of Chemistry and Radiology, University of Tennessee, Knoxville, Tennessee, USA
- 3 Advion Biosystems, Ithaca, NY, USA
- 4 Departments of Chemistry and Radiology, University of Tennessee, Knoxville, Tennessee, USA
International Journal of Organic Chemistry·Volume 06 (2016)·Pages 177–185·Published 19 September 2016·DOI10.4236/ijoc.2016.63018
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Abstract
[F-18]FBAM, a thiol reactive bifunctional agent, was successfully synthesized using continuous flow chemistry in a micro reactor that is part of Advion NanoTek Micro-fluidic Synthesizer. As the radiofluorination was carried out microfluidically, a very small amount of precursor was used and over all radiochemical yield was 38% ± 4% (n = 8, decay corrected) and the radiochemical purity was ≥98% with specific activity of 430 mC/μmol. The total reaction time including HPLC purification was 55 min that is 14 min more than manual synthesis and 6 min less than fully automated synthesis.
KeywordsBifunctional AgentMicro-Reactor6-BromohexnolRadiofluorinationAppel Reaction
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