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Two Flavones from <i>Acanthospermum hispidum</i> DC and Their Antibacterial Activity
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International Journal of Organic Chemistry·Volume 01 (2011)·Pages 132–141·Published 28 September 2011·DOI10.4236/ijoc.2011.13020
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Abstract
Two new flavones, namely 5,7,2’,5’-tetrahydroxy-3,4’-dimethoxyflavone and 5’-acetoxy-5,7,2’-trihydroxy-3, 4’-dimethoxyflavone were successfuly isolated from the leaves of <i>Acanthospermum hispidum</i> DC and identified by UV-Vis, IR, <sup>1</sup>H-NMR and EI-MS techniques. Both compounds exhibited antibacterial activity against Salmonella typii, Staphylococcus aureus, Klebsiella pneumoniae, Proteus mirabilis, Bacillus subtilis, Pseudomonas aeruginosa and Shigella dysenteriae with minimum inhibition concentration (MIC) ranging from 0.001 - 0.20 but was inactive against Escherichia coli, Corybacterium pyogenes and Proteus vulgaris.
Keywords<i>Acanthospermum hispidum</i>DCFlavonoidsAntibacterialSpectroscopy
- C. A. Olafimihan, “Antibacterial Efficacy of Citrus auran- tifolia,” Nigerian Society for Experimental Biology Jour- nal, Vol. 2, No. 2, 2002, pp. 165-167.
- D. Z. Egah, C. S. S. Bello, E. E. Banwat and J. A. Alana, “Antibacterial Susceptibility Pattern of S. aureus in Jos, Nigeria,” Nigerian Journal of Medicine, Vol. 8, No. 2, 1999, pp. 58-61.
- K. A. Abo, V. O. Ogunleye and J. S. Ashidi, “Antimicrobial Potential of Spondias mombin, Croton zambescus and Zygotritonia crocea,” Phytotherapy Research, Vol. 13, No. 6, pp. 494-497. doi:10.1002/(SICI)1099-1573(199909)13:6 3.0.CO;2-9
- A. A. Elegami, E. I. Elnima, A. K. Muddathir and M. E. Omer, “Antimicrobial Activity of Plicosepalus acacia,” Fitoterapia, Vol. 72, 2001, pp. 431-434.
- A. Islam, A. Sayeed, M. S. A. Bhuiyan, M. A. Mosadik, M. A. U. Islam and G. R. M Astaq Mondal Khan, “Antimicrobial Activity and Cytotoxicity of Zanthoxylum budrunga,” Fitoterapia, Vol. 72, 2001, pp. 428-430.
- J. O. Adebayo, M. T. Yakubu, E. C. Egwin, B. V. Owoeye and B. U. Enaibe, “Effect of Ethanolic Extract of Khaya senegalensis on Some Biochemical Parameters of Rat Kidney,” Journal of Ethnopharmacol, Vol. 88, No. 1, 2003, pp. 69-72. doi:10.1016/S0378-8741(03)00193-4
- A. G. R. Nair, S. A. Rao, B. Voirin, F. Favre and J. Bonvin, “Polyphenolic Compounds from Leaves of Acanthospermum hispidum,” Fitoterapia, Vol. 56, No. 4, 1985, pp. 240 - 250
- S. B. Mathur and L. B. Bejarane, “Isolation of Triacontane, N-Butil Eicosante and N-Heptacosanol from Acanthospermum hispidum,” Phytochemistry, Vol. 15, 1976, p. 2026.
- M. U. S. Sultanbawa, G. P. Wannigama and W. M. Bandaranayake, “Chemical Investigation of Ceylonese Plants. Part XXIX. A Survey of Plants of Sri Lanka (Ceylon) for Alkaloids I,” Lloydia, Vol. 41, 1978, pp. 597-633.
- N. A. G. Ramachandran, S. A. Rao and B. Voirin, “Polyphenolic Compounds from Leaves of Acantho- spermum hispidum,” Fitoterapia, Vol. 56, 1985, pp. 249- 251.
- F. Bohlmann, J. Jakupovic, C. Zdero, R. M. King and H. Robinson, “Naturally Occurring Terpene Derivatives, 179. New Melampolidis and Cis-Cis-Germacranolides from Members of the Subhibes Melanpodiinae,” Phytoche- mistry, Vol. 18, 1979, pp. 625-630.
- L. H. Yao, Y. M. Jiang, J. Shi, F. A. Tomás-Barberán, N. Datta, R. Singanusong and S. S. Chen, “Flavonoids in Food and Their Health Benefits,” Plant Foods for Human Nutrition, Vol. 59, 2004, pp. 113-122. doi:10.1007/s11130-004-0049-7