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Synthesis, Molecular Structure and Antibacterial Activity of Benzylmethyl-4-Methyl-3-Thiosemicarbazone
Department of Chemistry, University of Buea, Buea, Cameroon
Department of Chemistry, University of Buea, Buea, Cameroon
Department of Chemistry, University of Buea, Buea, Cameroon
Department of Chemistry, University of Buea, Buea, Cameroon
- 1 Department of Chemistry, University of Buea, Buea, Cameroon
- 2 Department of Chemistry, University of Buea, Buea, Cameroon
- 3 Department of Chemistry, University of Buea, Buea, Cameroon
- 4 Department of Chemistry, University of Buea, Buea, Cameroon
International Journal of Organic Chemistry·Volume 07 (2017)·Pages 83–90·Published 24 May 2017·DOI10.4236/ijoc.2017.72007
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Abstract
A novel Schiff base, benzylmethyl-4-methyl-3-thiosemicarbazone ( BMM ) de-rived from benzylmethylketone and 4-methylthiosemicarbazide was synthe-sized and characterized by elemental analysis, spectroscopic methods (IR, 1 H NMR, 13 C NMR) and physical means. The single crystal structure analysis of the Schiff base reveals that it crystallizes in a monoclinic system in the P2 1 /c space group. BMM revealed moderate antibacterial activity on three bacterial strains with diameter zone of inhibition of 16 mm ( E. coli ), 14 mm ( K. pneumonia ) and 13 mm ( S. epider-midis ) compared with the standard drug, ciprofloxacin.
KeywordsBenzylmethyl-4-Methyl-3-ThiosemicarbazoneAntibacterial ActivityCrystal Structure
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