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Solvent-Free Mechanochemical Deprotection of <i>N</i>-Boc Group
Division of Organic Chemistry and Biochemistry, Ruder Boskovic Institute, Zagreb, Croatia
Division of Organic Chemistry and Biochemistry, Ruder Boskovic Institute, Zagreb, Croatia
- 1 Division of Organic Chemistry and Biochemistry, Ruder Boskovic Institute, Zagreb, Croatia
- 2 Division of Organic Chemistry and Biochemistry, Ruder Boskovic Institute, Zagreb, Croatia
International Journal of Organic Chemistry·Volume 07 (2017)·Pages 140–144·Published 24 May 2017·DOI10.4236/ijoc.2017.72011
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Abstract
Boc protection group could be readily removed in a very mild mechanochemical conditions. In a short reaction time, ball milling of Boc-protected amines with p -toluenesulfonic acid in solvent-free conditions affords corresponding amine p -TsOH salts.
KeywordsGreen ChemistryMechanosynthesisBoc Deprotection
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