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Synthesis, Molecular Structure and Antibacterial Activity of 1-(4-Methoxybenzaldehyde)-4-Methylthiosemicarbazone
Department of Chemistry, University of Buea, Buea, Cameroon
Department of Chemistry, University of Buea, Buea, Cameroon
Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon
Department of Chemistry, University of Buea, Buea, Cameroon
Department of Chemistry, University of Buea, Buea, Cameroon
Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon
- 1 Department of Chemistry, University of Buea, Buea, Cameroon
- 2 Department of Chemistry, University of Buea, Buea, Cameroon
- 3 Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon
- 4 Department of Chemistry, University of Buea, Buea, Cameroon
- 5 Department of Chemistry, University of Buea, Buea, Cameroon
- 6 Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon
International Journal of Organic Chemistry·Volume 07 (2017)·Pages 229–239·Published 21 July 2017·DOI10.4236/ijoc.2017.73017
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Abstract
A novel ligand, 1-(4-methoxybenzylidene)-4-methylthiosemicarbazone (MBT) derived from 4-methoxybenzaldehyde was synthesized and characterized by spectroscopic methods (IR, 1 H NMR, 13 C NMR), single crystal X-ray diffraction technique and physical means. MBT showed antibacterial activity in vitro with MICs of 64 μg/mL (a strain of Salmonella typhi (ATCC 6539)), 128 μg/mL ( Salmonella typhi ), 64 μg/mL ( Salmonella paratyphi A ), 128 μg/mL ( Salmonella paratyphi B ) and 64 μg/mL ( Salmonella typhimurium ) . The results showed that MBT demonstrated moderate in vitro antibacterial activity against a strain of Salmonella typhi (ATCC 6539), Salmonella paratyphi A , and Salmonella typhimurium , indicating its promise as a possible lead for the discovery of antibacterial drugs.
KeywordsNovel Schiff BaseAntibacterial ActivityCrystal Structure
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