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Novel Route for Synthesis of Thiozolidine-2,4-Dione Derivatives as a Mannich Base
Department of Chemistry, Sri Krishnadevaraya University, Anantapur, India
Department of Chemistry, Sri Krishnadevaraya University, Anantapur, India
Department of Chemistry, Sri Krishnadevaraya University, Anantapur, India
- 1 Department of Chemistry, Sri Krishnadevaraya University, Anantapur, India
- 2 Department of Chemistry, Sri Krishnadevaraya University, Anantapur, India
- 3 Department of Chemistry, Sri Krishnadevaraya University, Anantapur, India
International Journal of Organic Chemistry·Volume 07 (2017)·Pages 269–283·Published 21 July 2017·DOI10.4236/ijoc.2017.73021
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Abstract
The Mannich base of Thiozolidine-2,4-dione derivatives has come to lime light due to their various pharmacological activities. Thiazolidine-2,4-dione is an extensively explored heterocyclic nucleus for designing of novel agents implicated for a wide variety of pathophysiological conditions, that is, diabetes, diabetic complications, cancer, arthritis, inflammation, microbial infection, and melanoma. In present work, synthesis quinoline attached imidazoline derivative using (3 + 2) cyclo-addition via imine of quinoline and TosMIC. These derivat ives were converted to Mannich bases of thiozolidine-2,4-dione using Knoevenagel condensation. The sulfonamide analogues of thiozolidine-2,4-Dione were also synthesized and characterized by using alkylation conditions.
KeywordsImidazole AnaloguesThiozolidine-24-Dione NucleusToluenesulfonylmethyl IsocyanideCombi-Flash Column Chromatography
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