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Synthesis and Antibacterial Activity of Aromatic Homopropargyl Alcohols
School of Chemistry, University of Costa Rica, San José, Costa Rica
Faculty of Microbiology, University of Costa Rica, San José, Costa Rica
School of Chemistry, University of Costa Rica, San José, Costa Rica
- 1 School of Chemistry, University of Costa Rica, San José, Costa Rica
- 2 Faculty of Microbiology, University of Costa Rica, San José, Costa Rica
- 3 School of Chemistry, University of Costa Rica, San José, Costa Rica
International Journal of Organic Chemistry·Volume 07 (2017)·Pages 295–300·Published 21 July 2017·DOI10.4236/ijoc.2017.73023
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Abstract
Several aromatic homopropargyl alcohols, and derivatives were prepared by one-pot reaction of 1,3-dilithiopropyne (or its equivalent) with aldehydes and ketones. The antibacterial activity, of alcohols thus prepared, against Gram (+) and Gram (-) bacteria was tested. This activity varies depending upon substitution on the homopropargyl alcohol unit. Apparently, the benzene ring and the free hydroxyl group (or its alcoxide) are needed, in the homopropargyl alcohol unit, to be biologically active.
KeywordsHomopropargyl Alcohols13-DilithiopropyneAntibacterial Activity
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