Novel fluorine substituted α -amino phosphonic acids containing 1,2,4-triazin- 5-one ( 6a - f ) have been obtained from fluoroacylation of 6-(2 ′ -amino-5 ′ -nitrophenyl)-3-thioxo-1,2,4-triazin-5(4H)-one ( 1 ) followed by ammonilysis to give the corresponding 3-amino-derivative 3 . Condensation of compound 3 with nitro/halogenated aromatic aldehydes yielded the Schiff bases 4 . The simple addition of diethyl phosphonate to compound 4 produced the α -amino phosphonates 5 . Acidic hydrolysis of compound 5 produced the fluorine substituted α -amino acids derivatives 6 . Structures of the new compounds have been established with the help of elemental analysis and spectral measurements. Also, the products evaluated as antioxidants, where the fluorinated α -amino phosphonic acids 6 are more active than the other synthesized systems.
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