Four easily available ferrocenyl chiral ligands have been screened firstly for ruthenium (II)-catalyzed asymmetric transfer hydrogenation of acetophenone with HCOOH/Et 3 N azeotrope as the hydrogen source. A moderate chemical yield of 1-phenylethanol with 83% ee was obtained when ( R C , S Fc )-1-(Diphe-nylphosphino)-2-[1- N -(3-methylpyridin-2-ylmethyl) ethyl] ferrocene ( L 1 ) was used. Particularly, both ruthenium and iridium could coordinate with L 1 to accomplish the asymmetric reduction of series of aromatic ketones separately. The desired products were achieved with up to 86% ee.<
KeywordsAsymmetric Transfer HydrogenationFerroceneLigandKetone
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