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Synthesis and Determination of Antitumor Activity of Jacaranone and Synthetic Analogs
ResearchCenter for Tropical Disease (CIET) and Faculty of Microbiology, University of Costa Rica, San José, Costa Rica
ResearchCenter for Tropical Disease (CIET) and Faculty of Microbiology, University of Costa Rica, San José, Costa Rica
School of Chemistry, University of Costa Rica, San José, Costa Rica
School of Chemistry, University of Costa Rica, San José, Costa Rica
- 1 ResearchCenter for Tropical Disease (CIET) and Faculty of Microbiology, University of Costa Rica, San José, Costa Rica
- 2 ResearchCenter for Tropical Disease (CIET) and Faculty of Microbiology, University of Costa Rica, San José, Costa Rica
- 3 School of Chemistry, University of Costa Rica, San José, Costa Rica
- 4 School of Chemistry, University of Costa Rica, San José, Costa Rica
International Journal of Organic Chemistry·Volume 08 (2018)·Pages 115–124·Published 15 January 2018·DOI10.4236/ijoc.2018.81007
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Abstract
Natural product jacaranone, 1 , and three analog derivatives were synthesized and their apoptotic and necrotic activity against four cancer cell lines was tested. One of these derivatives 7 , was more active than the natural product, and exhibited an important necrotic effect against three of the cell lines tested (ovarian carcinoma, liver cancer and breast cancer cells). Derivative 6 was more active than the natural product, and showed a significant apoptotic activity against breast cancer and ovarian carcinoma cells. Some derivatives analyzed in this study showed promising anti-tumor results, nevertheless, further studies have to be done in order to determine their in vivo activity, their mechanism as well as their safety and stability.
KeywordsJacaranoneJacaranone Synthetic AnalogsAntitumor Activity
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