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Synthesis and Antifungal Activity of Some New Fluorine-Substituted 4-Thiazolidinone Bearing 1,2,4-Triazinone
Department of Chemistry, Faculty of Science, King Abdul-Aziz University, Jeddah, KSA
- 1 Department of Chemistry, Faculty of Science, King Abdul-Aziz University, Jeddah, KSA
International Journal of Organic Chemistry·Volume 08 (2018)·Pages 170–175·Published 15 January 2018·DOI10.4236/ijoc.2018.81012
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Abstract
Fluorine substituted 4-thiazolidinone 5 bearing 1,2,4-triazinone obtained from the condensation of 3-Amino-6(2’-aminophenyl)-1,2,4-triazin-5(4H)-one ( 2 ) with an aromatic aldehyde followed by cycloaddition with mercaptoacetic acid afforded the thiazolidinone ( 4 ), and treatment with ethyl trifluoroacetate. Structure of the products has been deduced from their correct elemental analysis and spectral measurements. The antifungal activity of the new fluorinated target also has been evaluated.
KeywordsSynthesisFluorine4-Thiazolidinone124-Triazin Fungal
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