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Synthesis and Chiral Separation of Fibratol, Isopropyl 2-(4-((4-chlorophenyl)(hydroxyl) methyl)-phenoxy)-2-methylpropanoate
Department of Chemistry, Youngstown State University, One University Plaza, Youngstown, OH, USA
Medicinal Chemistry Division, Central Drug Research Institute, Lucknow, India
Department of Chemistry, Youngstown State University, One University Plaza, Youngstown, OH, USA
- 1 Department of Chemistry, Youngstown State University, One University Plaza, Youngstown, OH, USA
- 2 Medicinal Chemistry Division, Central Drug Research Institute, Lucknow, India
- 3 Department of Chemistry, Youngstown State University, One University Plaza, Youngstown, OH, USA
International Journal of Organic Chemistry·Volume 08 (2018)·Pages 201–206·Published 4 May 2018·DOI10.4236/ijoc.2018.82015
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Abstract
Practical synthetic route for the formation of enantiomeric mixture of Isopropyl 2-(4-((4-chlorophenyl)(hydroxyl)methyl)phenoxy)-2-methylpropanoate (Fibratol 2a/b) from isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate (Fenofibrate 1) has been developed. Method has also been established for the chiral separation of enantiomers of Fibratol 2a/b that is synthesized using the route mentioned above. The optical activity determined for enantiomerically separated Fibratol (2a) and Fibratol (2b) are -5.2 ° and 8.0 ° which reflect their ability to rotate plane polarized light counterclockwise ( levo ) and clockwise ( dextro ), respectively.
KeywordsReductionChiralityOptical ActivityFibrate
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