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Synthesis, Characterization and Antimicrobial Studies of Co(II), Ni(II), Cu(II) and Zn(II) Complexes of (E)-2-(4-Dimethylbenzydimino)-Glycylglycine, (Glygly-DAB) a Schiff Base Derived from 4-Dimethylaminobenzaldehyde and Glycylglycine
Department of Inorganic Chemistry, Faculty of Science, University of Yaounde 1, Yaoundé, Cameroon
Department of Chemistry, Faculty of Science, University of Douala, Douala, Cameroon
Department of Inorganic Chemistry, Faculty of Science, University of Yaounde 1, Yaoundé, Cameroon
Department of Inorganic Chemistry, Faculty of Science, University of Yaounde 1, Yaoundé, Cameroon
Department of Inorganic Chemistry, Faculty of Science, University of Yaounde 1, Yaoundé, Cameroon
Department of Inorganic Chemistry, Faculty of Science, University of Yaounde 1, Yaoundé, Cameroon
- 1 Department of Inorganic Chemistry, Faculty of Science, University of Yaounde 1, Yaoundé, Cameroon
- 2 Department of Chemistry, Faculty of Science, University of Douala, Douala, Cameroon
- 3 Department of Inorganic Chemistry, Faculty of Science, University of Yaounde 1, Yaoundé, Cameroon
- 4 Department of Inorganic Chemistry, Faculty of Science, University of Yaounde 1, Yaoundé, Cameroon
- 5 Department of Inorganic Chemistry, Faculty of Science, University of Yaounde 1, Yaoundé, Cameroon
- 6 Department of Inorganic Chemistry, Faculty of Science, University of Yaounde 1, Yaoundé, Cameroon
International Journal of Organic Chemistry·Volume 08 (2018)·Pages 298–308·Published 1 August 2018·DOI10.4236/ijoc.2018.83022
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Abstract
A tridentate Schiff base ligand, (E)-2-(4-dimethylbenzydimino) glycylglycine (glygly-DAB), derived from the condensation of 4-Dimethylaminobenzaldehyde (D AB) and glycylglycine (glygly) together with its Co(II), Ni(II), Cu(II) and Zn(II) complexes have been synthesized and characterized using various physico-chemical methods including C,H,N elemental analysis, melting point determination, molar conductivity measurement, IR, 1 H NMR and UV-Vis. The ligand and metal complexes were screened in vitro for antimicrobial and antifungal activities on four bacterial strains ( Staphylococcus aureus , Escherichia coli , Salmonella thyphi and Pseudomonas aeruginosa ) and two fungal strains ( Candida albicans and Cryptococcus neoformans ). glygly-DAB showed remarkable antifungal activities on all the fungal strains and antibacterial activities on one bacterial strain.
KeywordsSchiff Base LigandGlycylglycineComplexesAntimicrobial ActivitiesSpectroscopy
- Boghaei, M. and Mohebi, S. (2002) Non-Symmetrical TetradentateVanadyl Schiff Base Complexes Derived from 1, 2-Phenylene Diamine and 1,3-Naphthalenediamine as Catalyst for the Oxidation of Cyclohexene. Tetrahedron, 58, 5357-5366. https://doi.org/10.1016/S0040-4020(02)00481-7
- Ndifon, P., Agwara, M., Njapha, J., Yufenyi, D., Paboudam, A. and Nyamen, L. (2010) Synthesis, Characterization and Antimicrobial Activity of Cu(II) and Zn(II) Complexes of Schiff Bases Derived from Amino Acids and 1,10-Phenanthroline Mixed Ligands. Research Journal of Chemistry and Environment, 14, 50-54.
- Eman, A., Khaled, H., Safaa, K. and Nabil, S. (2008) Synthesis, Characterization and Biological Activity of Some Transition Metal Complexes with Schiff Bases Derived from 2-Formylindole, Salicyladehyde, and N-Amino Rhodanine. Australian Journal of Basic and Applied Sciences, 2, 210-220.
- Berkesi, O., Kortvélyesi, T., Hetényi, C., Németh, T. and Pálinkó, I. (2003) Hydrogen Bonding Interaction of Benzylidene Type Schiff Bases Studied by Vibrational Spectroscopic and Computational Methods. Physical Chemistry Chemical Physics, 5, 2009-2014. https://doi.org/10.1039/B301107K
- Mounika, K., Anupama, B., Pragathi, J. and Gyanakumari, C. (2010) Synthesis, Characterization and Biological Activity of a Schiff Base Derived from 3-Ethoxy Salicylaldehyde and 2-Amino Benzoic Acid and Its Transition Metal Complexes. Journal of Scientific Research, 2, 513-524.
- Pier, G., (2004) Metal-Salen Schiff Base Complexes in Catalysis: Practical Aspects, Chemical Society Reviews, 33, 410-421. https://doi.org/10.1039/B307853C
- Prakasha, C., Raghavendra, M., Harisha, R. and Gowda, C. (2011) Design, Synthesis and Antimicrobial Screening of Amino Acids Conjugated 2-Amino-4-arylthiazole Derivatives. International Journal of Pharmacy and Pharmaceutical Sciences, 3, 120-122.
- Gajendra, K., Dharmendra, K., Shoma, D., Amit, K. and Rajeev, J. (2010) Synthesis, Physical Characterization and Biological Evaluation of Schiff Base Cr(III), Mn(III) and Fe(III) Complexes. E-Journal of Chemistry, 7, 813-820. https://doi.org/10.1155/2010/623915
- Sharma, K.K., Singh, R., Fahmi, N. and Singh, R.V. (2010) Synthesis, Coordination Behavior, and Investigations of Pharmacological Effects of Some Transition Metal Complexes with Isoniazid Schiff Bases. Journal of Coordination Chemistry, 60, 3071-3082. https://doi.org/10.1080/00958972.2010.504986
- Nguyen, N., To, M., Carles, M., Tripodi, A. and Bodin, G. (2000) Etude de 91 souches d’Escherichia coli responsables de la maladie de l’ædème. Revue de Médecine, 151, 23-32.