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Synthesis of Some New Thioethers and 4-Thiazolidinones Bearing 3-(Pyridine-4'-yl)-1,2,4-Triazino[5,6-<i>b</i>]Indole Moiety as Antifungal Agents
Department of Chemistry, Faculty of Science, KAU, Jeddah, Saudi Arabia
- 1 Department of Chemistry, Faculty of Science, KAU, Jeddah, Saudi Arabia
International Journal of Organic Chemistry·Volume 09 (2019)·Pages 37–46·Published 11 January 2019·DOI10.4236/ijoc.2019.91004
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Abstract
Some new asymmetric thioethers 5 and 4-thiazolidinones 6 have been obtained from condensation of 5-formyl-3-(pyridin-4'-yl)-1,2,4-triazino[5,6- b ] indole ( 3 ) with halogenated aromatic amines followed by addition of thiophenol and/or cycloaddition with thiolactic acids in nonpolar solvents. Structures of the products confirmed by elemental analysis and spectral measurements. The new systems obtained were evaluated as antifungal agents.
KeywordsThioethersThiazolidnones124-Triazino IndoleFungicidalCycloaddition
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