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Efficient Cross-Coupling Reaction of Aryltrifluoroborates and Aroyl Chlorides for the Synthesis of Fluorine Substituted Aromatic Ketones
Department of Chemistry, Tennessee State University, Nashville, TN, USA
Department of Chemistry, Tennessee State University, Nashville, TN, USA
Department of Chemistry, Tennessee State University, Nashville, TN, USA
- 1 Department of Chemistry, Tennessee State University, Nashville, TN, USA
- 2 Department of Chemistry, Tennessee State University, Nashville, TN, USA
- 3 Department of Chemistry, Tennessee State University, Nashville, TN, USA
International Journal of Organic Chemistry·Volume 09 (2019)·Pages 67–72·Published 11 January 2019·DOI10.4236/ijoc.2019.91006
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Abstract
The direct aroylation of ArCOPdCl with potassium aryltrifluoroborates establishes a new cross-coupling synthetic tool for the synthesis of various fluorine substituted benzophenones. The new microwave irradiated process is very efficient and produce high yield benzophenone products within minutes.
KeywordsArBF<sub>3</sub>KAroyl ChloridesDirect Aroylation to KetonesMinute Reaction
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