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Synthesis of Novel 4-Thiazolidinone and Bis-Thiazalidin-4-One Derivatives Derived from 4-Amino-Antipyrine and Evaluated as Inhibition of Purine Metabolism Enzymes by Bacteria
Department of Chemistry, Faculty of Science, King Abdul Aziz University, Jeddah, Saudi Arabia
Department of Chemistry, Faculty of Science, King Abdul Aziz University, Jeddah, Saudi Arabia
Department of Chemistry, Faculty of Science, Northern Borders University, Rafha, Saudi Arabia
- 1 Department of Chemistry, Faculty of Science, King Abdul Aziz University, Jeddah, Saudi Arabia
- 2 Department of Chemistry, Faculty of Science, King Abdul Aziz University, Jeddah, Saudi Arabia
- 3 Department of Chemistry, Faculty of Science, Northern Borders University, Rafha, Saudi Arabia
International Journal of Organic Chemistry·Volume 09 (2019)·Pages 85–95·Published 11 June 2019·DOI10.4236/ijoc.2019.92008
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Abstract
Novel 4-thiazolidione and 1,4-bis-thiazolidinone derivatives bearing antipyrine moiety have been obtained from condensation of 4-aminoantipyrine 1 with aromatic/heteroaldehydes followed by cycloaddition with mercaptoacetic acid in nonpolar solvents. Structure of the products has been deduced upon their elemental analysis and spectral measurements. Most of the targets evaluated as enzymatic effect towards some bacteria ( E. coli ) in compare with Xanthine oxidase (from buttermilk) where the role of compounds is an inhibition of purine metabolism enzymes caused by E. coli .
KeywordsSynthesis4-ThiazolidinonesAntipyrineInhibition of Purine Metabolism EnzymesBacteria
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