New Approach for the Determination of Tricyclic Antidepressant Amitriptyline Using <i>β</i>-Cyclodextrin-PEG System via Spectrophotomerty
- 1 Department of Applied Chemistry, Faculty of Engineering & Technology, Shri Shankaracharya Group of Institutions, Junwani, Bhilai, India
- 2 Department of Engineering Chemistry, Bhilai Institute of Technology, Bhilai House, Durg, India
- 3 Department of Applied Chemistry, Faculty of Engineering & Technology, Shri Shankaracharya Group of Institutions, Junwani, Bhilai, India
Abstract
A new and simple procedure for the spectrophotometric determination of the tricyclic antidepressant drug amitriptyline is proposed. The method is based on enhancement of sensitivity of the [AMIYTP]+ β -cyclodextrin and PEG molecules involved in formation of molecules inclusion complex, in presence of polyethylene glycol (PEG) medium. The mole ratio of [AMIYTP]+ β-cyclodextrin and PEG molecules in inclusion complex were determined by the curve fitting method. The value of molar absorptivity of {[AMIYTP: ( β CD)] PEG} complex in term of the drug lies in rage of (2.20 - 2.23) × 104 L·mole–1·cm–1 at absorption maximum 242 nm. The slope, intercept and correlation co-efficient were found to be 14.21, 0.0046, and 0.998, respectively. The effect of analytical variables on the determination of the drug and composition of the ion associated complex are discussed in the paper. This method is applicable in the determina-tion of amitriptyline in the pharmaceutical preparations.
- G. A. Gilman, W. T. Rall, S. A. Nies and P. Taylor, “The Pharmacological Basis of Therapeutics,” Ninth Edition, Mc Graw Hill, New York, 1996.
- C. M. Hall and R. A. Nugent, “Encyclopedia of Chemical Technology,” John Wiley & Sons, New York, 1992.
- W. C. Bowman and M. L. Rand, “Textbook of Pharmacology,” Blackwell Science Publication, London, 1992.
- J. L. Atwood, J. E. D. Daviess, D. D. Mac Nicol and F. Vogtle, “Comprehensive Supramolecular Chemistry Pergamon,” Oxford, 1996.
- K. A. Connors, “The Stability of Cyclodextrine Complex in Solution,” Chemical Reviews, Vol. 97, No. 5, 1997, pp. 1325-1357. doi:10.1021/cr960371r
- V. T. D’Souza and K. B. Lipkowitz, “Cyclodextrines,” Chemical Reviews, Vol. 98, 1998, p. 1741.
- D. O. Thompson, “Cyclodextrine—Enabling Excipients. Their Present and Future Use in Pharmaceuticals,” Critical Reviews in Therapeutic Drug Carrier, Vol. 14, No. 1, 1997, pp. 1-104.
- F. A. Mohamed, H. A. Mohamed, S. A. Hussein and S. A. Ahmed, “A Validated Spectrofluorimeter Method for Determination of Some Psychoactive Drug,” Journal of Pharmaceutical and Biomedical Analysis, Vol. 39, No. 1-2, 2005, pp. 139-146. doi:10.1016/j.jpba.2005.03.024
- J. E. F. Reynolds (Ed.), “The Extra Pharmacopoeia,” 30th Edition, The Pharmaceutical Press, London, 1993, p. 8140.
- J. Karpinska, J. Suszymska and J. Trace, “The Spectrophometric Simultaneous Determination of Amitriptyline and Chloropromazine Hydrochloride in Their Binary Mixture,” Microprobe Technology, Vol. 19, 2001, pp. 355-364. doi:10.1081/TMA-100105051
- A. F. Faten, N. El-Dien, G. Mohamed Gehad and A. Mohamed, “Nehad Spectrophoto Metric Determination of Aminopline, Trazodone, Amitriptyline through Using Methyl Orange and Bromocresol Green Reagent,” Spectrochemi Acta Part A, Vol. 65, 2006, pp. 26-30.
- A. Tehssen, A. A Kazi, I. H. Mohamed and A. Tal, “Spectrophotometric Determination of Amitriptyline Hydrochloride in Pure and Pharmaceutical Preparation,” Analytical letters, Vol. 33, No. 12, 2000, pp. 2477-2490. doi:10.1080/00032710008543203
- J. O. Onah, “Spectrophotometric Determination of Amitriptyline by Method of Charge Transfer Complexation with Chloranic,” Acid Global Journal of Puro and Applied Science, Vol. 11, No. 2, 2005.
- W. Micink and M. Tarasiewicz, “Application of Thiocynate Complex of Titanium (iv) to the Extractive Spectrophotometric Determination of Amitriptyline Hydrochloride,” Microchemical Journal, Vol. 78, No. 107, 1993, pp. 79-88,