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Application of Optical Methods in Blood Studies upon Evaluation of Severity Rate of Diffuse Liver Pathology
Institute of Internal Medicine, SB RAMS, Novosibirsk, Russia
Institute of Internal Medicine, SB RAMS, Novosibirsk, Russia
Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia
Institute of Internal Medicine, SB RAMS, Novosibirsk, Russia
Institute of Internal Medicine, SB RAMS, Novosibirsk, Russia
Rzhanov Institute of Semiconductor Physics, SB RAS, Novosibirsk, Russia
Rzhanov Institute of Semiconductor Physics, SB RAS, Novosibirsk, Russia
Rzhanov Institute of Semiconductor Physics, SB RAS, Novosibirsk, Russia
State Research Center of Virology and Biotechnology, Ministry of Public Health and Social Development of the Russian Federation, Koltsovo, Russia
- 1 Institute of Internal Medicine, SB RAMS, Novosibirsk, Russia
- 2 Institute of Internal Medicine, SB RAMS, Novosibirsk, Russia
- 3 Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia
- 4 Institute of Internal Medicine, SB RAMS, Novosibirsk, Russia
- 5 Institute of Internal Medicine, SB RAMS, Novosibirsk, Russia
- 6 Rzhanov Institute of Semiconductor Physics, SB RAS, Novosibirsk, Russia
- 7 Rzhanov Institute of Semiconductor Physics, SB RAS, Novosibirsk, Russia
- 8 Rzhanov Institute of Semiconductor Physics, SB RAS, Novosibirsk, Russia
- 9 State Research Center of Virology and Biotechnology, Ministry of Public Health and Social Development of the Russian Federation, Koltsovo, Russia
Journal of Analytical Sciences, Methods and Instrumentation·Volume 03 (2013)·Pages 115–123·Published 31 May 2013·DOI10.4236/jasmi.2013.32014
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Abstract
Possible early diagnostic application of optical methods ( dielectrophoresis , spectral and imaging ellipsometry , Fourier-transform infrared spectroscopy , Raman spectroscopy ) in studies of red blood cells and serum of patients with diffuse liver disease with varying degrees of fibrosis has been evaluated. Application of combined optical methods was confirmed to significantly improve the performance of sensitivity, specificity, and accuracy index as well as to achieve the reliable results in diagnosis of both severe fibrosis and slight ulterior liver fibrosis. Identified diagnostic potential of optical methods can be effectively utilized in noninvasive screening evaluation of stages of diffuse liver disease of various geneses .
KeywordsOptical MethodsBlood Serum StudiesErythrocytesDiffuse Liver DiseaseDegree of FibrosisDielectrophoresisEllipsometryRaman SpectroscopyIR Fourier Spectroscopy
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