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Correlation of Serum Cytokines in Patients with Post-Traumatic Stress Disorder
Department of Endocrinology, The Fourth People’s Hospital of Haikou, Haikou, China
Department of Psychology, Hainan General Hospital, Haikou, China
- 1 Department of Endocrinology, The Fourth People’s Hospital of Haikou, Haikou, China
- 2 Department of Psychology, Hainan General Hospital, Haikou, China
Journal of Behavioral and Brain Science·Volume 11 (2021)·Pages 281–285·Published 16 December 2021·DOI10.4236/jbbs.2021.1112023
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Abstract
Objective: The objective is to investigate the correlation between post-traumatic stress disorder (PTSD) and serum cytokines in Hainan. Methods: The serum levels of IL-2, IL-4, IL-6 and IL-8 were detected by enzyme-linked immunosorbent assay (ELISA) in 60 post-traumatic stress disorder patients and 60 healthy controls in Hainan. Results: The se-rum levels of IL-2 (t = 15.981, P = 0.000), IL-6 (t = 20.984, P = 0.000) and IL-8 (t = 6.906, P = 0.000) in PTSD group were significantly higher than those in control group. There was no significant difference in serum IL-4 content be-tween the two groups (t = 1.109), P = 0.259). Conclusion: POST-traumatic stress disorder is closely related to the changes of serum cyto-kines, and IL-2, IL-6 and IL-8 may play an important role in the pathogenesis of PTSD.
KeywordsPost-Traumatic Stress DisorderCytokinesIL-2IL-4IL-6IL-8
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