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The Diagnostic Value of Oligoclonal Band Detection in Viral Encephalitis
Department of Neurology, Liaocheng Hospital Affiliated to Shandong First Medical University (Liaocheng People’s Hospital), Liaocheng, China
Department of Neurology, Liaocheng Hospital Affiliated to Shandong First Medical University (Liaocheng People’s Hospital), Liaocheng, China
Department of Neurology, Liaocheng Hospital Affiliated to Shandong First Medical University (Liaocheng People’s Hospital), Liaocheng, China
- 1 Department of Neurology, Liaocheng Hospital Affiliated to Shandong First Medical University (Liaocheng People’s Hospital), Liaocheng, China
- 2 Department of Neurology, Liaocheng Hospital Affiliated to Shandong First Medical University (Liaocheng People’s Hospital), Liaocheng, China
- 3 Department of Neurology, Liaocheng Hospital Affiliated to Shandong First Medical University (Liaocheng People’s Hospital), Liaocheng, China
Journal of Behavioral and Brain Science·Volume 14 (2024)·Pages 23–31·Published 16 January 2024·DOI10.4236/jbbs.2024.141003
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Abstract
Objective: This study aims to explore the differences in cerebrospinal fluid oligoclonal band (CSF-OCB) expression among different age groups in viral encephalitis and its reference value for diagnosis. Methods: Forty-two patients with viral encephalitis were divided into two groups: 25 adults and 17 children. The presence of oligoclonal bands in the cerebrospinal fluid (CSF) was detected using polyacrylamide gel electrophoresis, and CSF routine analysis was conducted for comparative analysis. Results: The CSF-OCB positivity rate was higher in the adult group (48%) compared with the pediatric group (11.76%), with a statistically significant difference (P Conclusion: 1) The expression of CSF-OCB positivity in patients with viral encephalitis is age-related, with higher positivity rates observed in adults compared to children. 2) Although CSF oligoclonal band detection is not a specific diagnostic marker for viral encephalitis in adults, it still holds certain reference value.
KeywordsOligoclonal Band DetectionViral EncephalitisRoutine Analysis of Cerebrospinal FluidAge
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