Effects of Pearl Yangxin Anshen Decoction on HAMD and PTSD-SS Scores, Cytokines and Related Metabolites in Patients with Post-Traumatic Stress Disorder
- 1 Department of Gastroenterology, The Fourth People’s Hospital of Haikou, Haikou, China
- 2 Department of Gastroenterology, The Fourth People’s Hospital of Haikou, Haikou, China
Abstract
Objective: This paper aims to observe the Pearl Yangxin Anshen Decoction to influence the score of HAMD and PTSD-SS, the changes of the cytokines and the related metabolic product in patients with PTSD. Methods: From June 2015 to May 2016, in the traditional Chinese medicine clinics of Hainan Province People’s Hospital, there were 50 patients with PTSD, the age were from 30 to 60, they were randomly divided into treatment group (25 cases) and control group (25 cases), then compared the scores of HAMD and PTSD-SS between the two groups, searched the changes of cytokines and the related metabolic product. Results: In the treatment group: before and after treatment the scores of PTSD-SS were 65.64 ± 7.02, 28.32 ± 4.18, and the scores of HAMD were 29.28 ± 1.97, 11.72 ± 2.13; In the control group: before and after treatment the scores of PTSD-SS were 63.24 ± 6.16, 31.40 ± 4.29, the scores of HAMD were 30.24 ± 2.05, 13.08 ± 2.30. After 3 months patients in treatment group the scores of PTSD-SS and HAMD were lower than the control group (t = 2.570, P = 0.013, t = -2.1640, P = 0.035). In the control group: before and after 3 months treatment the IL-2 levels respectively were 79.84 ± 26.46 pg/ml, 56.18 ± 22.67 pg/ml, the IL-6 levels respectively were 110.83 ± 47.65 pg/ml, 59.67 ± 44.68 pg/ml, the IL-8 levels respectively were 73.11 ± 78.51 pg/ml, 55.83 ± 81.94 pg/ml, the NE levels respectively were 420.04 ± 674.75 pg/ml, 185.31 ± 417.91 pg/ml, the MDA levels respectively were 112.35 ± 62.87 ng/ml, 60.42.33 ± 53.64 ng/ml, the NO levels were 126.6 ± 47.4 μmol/L, 78.6 ± 45.7 μmol/L, the VIP levels were 396.6 ± 144.4 pg/ml, 122.4 ± 111.5 pg/ml. In the treatment group: before and after 3 months treatment the IL-2 levels respectively were 86.00 ± 32.29 pg/ml, 53.84 ± 27.01 pg/ml, the IL-6 levels respectively were 108.21 ± 44.60 pg/ml, 42.46 ± 42.16 pg/ml, the IL-8 levels respectively were 81.48 ± 94.19 pg/ml, 54.07 ± 84.15 pg/ml, the NE levels respectively were 392.93 ± 592.84 pg/ml, 243.85 ± 588.45 pg/ml, the MDA levels respectively were 117.58 ± 63.37 ng/ml, 45.91 ± 38.94 ng/ml, the NO levels respectively were 135.9 ± 46.4 μmol/L, 72.6 ± 46.6 μmol/L, the VIP levels respectively were 414.0 ± 140.1 pg/ml, 185.8 ± 105.3 pg/ml. In the two groups as the extension of treatment time, the content of IL-2, IL-8, IL-6, NE, MDA, NO, and VIP were gradually reduced, and the level of reduction of the treatment group patients was higher than the control group, the change of ACTH and SOD levels just the opposite. Conclusion: The Pearl Yangxin Anshen Decoction could improve the symptoms of psychological anxiety, depression and other psychological problems in patients with PTSD, and influence the change of cytokines and related metabolites product.
- Liu, X.C., Ma, D.D., Liu, L.Q., et al. (1998) Research on Reliability and Validity of Self-Rating Scale for Post-Traumatic Stress Disorder. Chinese Journal of Behavioral Medicine, 7, 93-96.
- Lin, L., Wu, Y.X. and He, G.P. (2009) Study on Occupational Post-Traumatic Stress Disorder and Coping Style of Nurses in Emergency Department. Journal of Nursing Science, 24, 3-4. (In Chinese)
- Liu, X.C., Ma, D.D. and Liu, L.Q. (1998) Research on Reliability and Validity of Self-Rating Scale for Post-Traumatic Stress Disorder. Chinese Journal of Behavioral Medicine, 7, 93-96.
- Fan, Y.W., Sun, Y.Y., Guan, R.Y., et al. (2009) Investigation on PTSD and Mental Health Status of Primary and Secondary School Students in Earthquake Area. Advances in Psychological Science, 17, 393-397.
- Cai, G.X. (2011) Emotional Medicine. People’s Medical Publishing House, Beijing, 134.
- Wei, P.K., Xiu, L.J., Pang, B., et al. (2010) Effect of Bailong Jieyu Granules on Post-Traumatic Stress Disorder after Earthquake Disaster. Journal of Traditional Chinese Medicine, 5, 510-512.
- Zhong, H.W. (2000) Recent Status of Acupuncture and Moxibustion in Treatment of Mental Disorders. Chinese Acupuncture and Moxibustion, 59-60.
- Huang, R.W. and Wu, S.Y. (2021) Research Progress on Clinical Diagnosis and Psychological Intervention of Post-Traumatic Stress Disorder. Chinese Clinical Medicine, 28, 316.
- Yang, S.J., Chen, Y.Z. and Zhu, G.Q. (2021) From the Heart. Study on the Pathogenesis of Post-Traumatic Stress Disorder and the Prevention and Treatment of Traditional Chinese Medicine. Journal of Clinical Chinese Medicine, 33, 1011.
- Liu, X., Xie, D.J., Wang, X., et al. (2019) Clinical Study of Anshen Dingzhi Pill plus Escitalopram on Panic Disorder. Journal of Clinical Chinese Medicine, 31, 2281.