Conditioned Place Preference Deficits in Adulthood Following High Fat and High Sugar Diet Intake in Pre- and Periadolescence: A Test of the Specificity Hypothesis — Oak Academic Publishing
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Conditioned Place Preference Deficits in Adulthood Following High Fat and High Sugar Diet Intake in Pre- and Periadolescence: A Test of the Specificity Hypothesis
Department of Psychology, Saint Bonaventure University, St. Bonaventure, USA
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Department of Psychology, Saint Bonaventure University, St. Bonaventure, USA
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Department of Psychology, Saint Bonaventure University, St. Bonaventure, USA
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Department of Psychology, Saint Bonaventure University, St. Bonaventure, USA
1 Department of Psychology, Saint Bonaventure University, St. Bonaventure, USA
2 Department of Psychology, Saint Bonaventure University, St. Bonaventure, USA
3 Department of Psychology, Saint Bonaventure University, St. Bonaventure, USA
4 Department of Psychology, Saint Bonaventure University, St. Bonaventure, USA
Obesity is linked to poorer cognitive performance, both of which may result from eating high-fat foods during development. In the present study, pre - and periadolescent (postnatal days 21 to 40) male rats were fed high fat (HF), high sugar (HS), or rodent chow (Chow) diets. After conditioning for 16 days with either Cheetos ? (high-fat) or Froot Loops ? (high-sugar) unconditioned stimuli (US) on one side of a conditioned place preference (CPP) apparatus, rats were tested on postnatal day 61 for a place preference. Chow rats preferred the US-paired side, but HF rats showed no preference. HS rats preferred the side paired with Cheetos ? but not with Froot Loops ? . In spite of these deficits, object recognition, a nonassociative learning task, was not impaired. These results show mixed support for the specificity hypothesis, which predicts that CPP deficits will be nutrient-specific. The results show for the first time that eating a HS diet leads to a nutrient-specific CPP deficit (for HS foods), whereas eating a HF diet leads to a general CPP deficit (for HS and HF foods).
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