Functional magnetic resonance imaging (fMRI) was used to assess the activity of supplementary motor area (SMA) in six right-handed and six left-handed healthy volunteers. Two manual tasks (self-initiated previously practiced and unpredictable visually guided) were used. Quantitative analysis of hemispheric and bilateral SMA activation was described as mean ± standard deviation of hot spots/total spots. The two tasks induced bilateral SMA activation. The laterality of SMA activation was affected by manual dominance. Left SMA was significantly more activated in right- and left-handers while performing the motor tasks with the right hand. Right SMA was more activated in the left-handers when the left hand was used. Task complexity was the most important factor influencing the degree of SMA activation.
KeywordsFunctional Magnetic Resonance ImagingMotor ControlSupplementary Motor AreaLateralityHandedness
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