Brain Activation in the Prefrontal Cortex during Motor and Cognitive Tasks in Adults — Oak Academic Publishing
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Brain Activation in the Prefrontal Cortex during Motor and Cognitive Tasks in Adults
Department of Physical Therapy, University of Evansville, Evansville, IN, USA
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Department of Nutrition Sciences, College of Nursing and Health Professions, School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, USA
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Department of Kinesiology & Applied Physiology, Biomechanics and Movement Science Program, University of Delaware, Newark, DE, USA
1 Department of Physical Therapy, University of Evansville, Evansville, IN, USA
2 Department of Nutrition Sciences, College of Nursing and Health Professions, School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, USA
3 Department of Kinesiology & Applied Physiology, Biomechanics and Movement Science Program, University of Delaware, Newark, DE, USA
The prefrontal cortex (PFC) plays an important role in cognitive function, involved in Executive Functions (EFs) such as planning, working memory, and inhibition. Activation in the PFC also occurs during some motor activities. One commonly used tool to assess EF is the Tower of Hanoi, demonstrating sensitivity to PFC dysfunction. However, limited neuroimaging evidence is available to support the contribution of the PFC in the Tower of Hanoi task. In the current study, we use functional near infrared (fNIR) spectroscopy to examine hemodynamic responses associated with neural activity in the PFC in adults as they participate in the Tower of Hanoi task. We compared changes in cerebral oxygenation during resting, a motor task (tapping), and the Tower of Hanoi in 16 neurotypical adults, with measures of relative changes in concentration of oxygenated hemoglobin (Δoxy-Hb) and deoxygenated hemoglobin (Δdeoxy-Hb) taken throughout tasks, as well as total hemoglobin (ΔHbT) and oxygenation (Δoxy). Performance on the Tower of Hanoi was measured by the number of moves used to complete each level and the highest level of successful performance (3, 4, or 5 disks). We found a significant higher value of Δoxy-Hb and Δoxy in dorsolateral PFC (DLPFC) during the Tower of Hanoi as compared to tapping and resting. Significant changes in Δdeoxy-Hb and ΔHbT during the Tower of Hanoi were found in the right DLPFC only. These results support the notion that the Tower of Hanoi task requires higher levels of PFC activity than a similar motor task with low executive function demands.
KeywordsPrefrontal CortexFunctional Near Infrared (fNIR)Cognitive TaskTower of Hanoi
Bortoletto, M. and Cunnington, R. (2010) Motor Timing and Motor Sequencing Contribute Differently to the Preparation for Voluntary Movement. Neuroimage, 49, 3338-3348. http://dx.doi.org/10.1016/j.neuroimage.2009.11.048
Koenraadt, K.L., Roelofsen, E.G., Duysens, J. and Keijsers, N.L. (2014) Cortical Control of Normal Gait and precision Stepping: An fNIRS Study. Neuroimage, 85, 415-422. http://dx.doi.org/10.1016/j.neuroimage.2013.04.070
Krams, M., Rushworth, M.F., Deiber, M.P., Frackowiak, R.S. and Passingham, R.E. (1998) The Preparation, Execution and Suppression of Copied Movements in the Human Brain. Experimental Brain Research, 120, 386-398. http://dx.doi.org/10.1007/s002210050412
Goel, V. and Grafman, J. (1995) Are the Frontal Lobes Implicated in “Planning” Functions? Interpreting Data from the Tower of Hanoi. Neuropsychologia, 33, 623-642. http://dx.doi.org/10.1016/0028-3932(95)90866-P
Welsh, M.C. and Huizinga, M. (2005) Tower of Hanoi Disk-Transfer Task: Influences of Strategy Knowledge and Learning on Performance. Learning and Individual Differences, 15, 283-298. http://dx.doi.org/10.1016/j.lindif.2005.05.002
Welsh, M.C., Satterlee-Cartmell, T. and Stine, M. (1999) Towers of Hanoi and London: Contribution of Working Memory and Inhibition to Performance. Brain and Cognition, 41, 231-242. http://dx.doi.org/10.1006/brcg.1999.1123
Fincham, J.M., Carter, C.S., van Veen, V., Stenger, V.A. and Anderson, J.R. (2002) Neural Mechanisms of Planning: A Computational Analysis Using Event-Related fMRI. Proceedings of the National Academy of Sciences of the United States of America, 99, 3346-3351. http://dx.doi.org/10.1073/pnas.052703399
Guevara, M.A., Hernandez Gonzalez, M., Rizo Martinez, L.E. and Robles Aguirre, F.A. (2013) Performance of the Towers of Hanoi Task and Cortical Electroencephalographic Power Changes Associated with Infancy, Adolescence, and Early Adulthood. Experimental Brain Research, 231, 315-324. http://dx.doi.org/10.1007/s00221-013-3693-z
Guevara, M.A., Rizo Martinez, L.E., Robles Aguirre, F.A. and Hernandez Gonzalez, M. (2012) Prefrontal-Parietal Correlation during Performance of the Towers of Hanoi Task in Male Children, Adolescents and Young Adults. Developmental Cognitive Neuroscience, 2, 129-138. http://dx.doi.org/10.1016/j.dcn.2011.05.002
Babiloni, C., Pizzella, V., Gratta, C.D., Ferretti, A. and Romani, G.L. (2009) Fundamentals of Electroencefalography, Magnetoencefalography, and Functional Magnetic Resonance Imaging. International Review of Neurobiology, 86, 67-80. http://dx.doi.org/10.1016/S0074-7742(09)86005-4
Chance, B., Anday, E., Nioka, S., Zhou, S., Hong, L., Worden, K., Li, C., Murray, T., Ovetsky, Y., Pidikiti, D. and Thomas, R. (1998) A Novel Method for Fast Imaging of Brain Function, Non-Invasively, with Light. Optics Express, 2, 411-423. http://dx.doi.org/10.1364/OE.2.000411
Dieler, A.C., Tupak, S.V. and Fallgatter, A.J. (2012) Functional Near-Infrared Spectroscopy for the Assessment of Speech Related Tasks. Brain and Language, 121, 90-109. http://dx.doi.org/10.1016/j.bandl.2011.03.005
Lloyd-Fox, S., Blasi, A. and Elwell, C.E. (2010) Illuminating the Developing Brain: The Past, Present and Future of Functional Near Infrared Spectroscopy. Neuroscience & Biobehavioral Reviews, 34, 269-284. http://dx.doi.org/10.1016/j.neubiorev.2009.07.008
Ayaz, H., Izzetoglu, M., Shewokis, P.A. and Onaral, B. (2010) Sliding-Window Motion Artifact Rejection for Functional Near-Infrared Spectroscopy. 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Buenos Aires, 31 August-4 September 2010, 6567-6570.
Izzetoglu, M., Chitrapu, P., Bunce, S. and Onaral, B. (2010) Motion Artifact Cancellation in NIR Spectroscopy Using Discrete Kalman Filtering. Biomedical Engineering Online, 9, 16. http://dx.doi.org/10.1186/1475-925X-9-16
Fitts, P.M. (1954) The Information Capacity of the Human Motor System in Controlling the Amplitude of Movement. Journal of Experimental Psychology, 47, 381-391. http://dx.doi.org/10.1037/h0055392
Jobsis, F.F. (1977) Noninvasive, Infrared Monitoring of Cerebral and Myocardial Oxygen Sufficiency and Circulatory Parameters. Science, 198, 1264-1267. http://dx.doi.org/10.1126/science.929199
Okada, E. and Delpy, D.T. (2003) Near-Infrared Light Propagation in an Adult Head Model. II. Effect of Superficial Tissue Thickness on the Sensitivity of the Near-Infrared Spectroscopy Signal. Applied Optics, 42, 2915-2922. http://dx.doi.org/10.1364/AO.42.002915
Okada, E. and Delpy, D.T. (2003) Near-Infrared Light Propagation in an Adult Head Model. I. Modeling of Low-Level Scattering in the Cerebrospinal Fluid Layer. Applied Optics, 42, 2906-2914. http://dx.doi.org/10.1364/AO.42.002906
Izzetoglu, M., Izzetoglu, K., Bunce, S., Ayaz, H., Devaraj, A., Onaral, B. and Pourrezaei, K. (2005) Functional Near-Infrared Neuroimaging. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 13, 153-159. http://dx.doi.org/10.1109/TNSRE.2005.847377
Chance, B., Zhuang, Z., UnAh, C., Alter, C. and Lipton, L. (1993) Cognition-Activated Low-Frequency Modulation of Light Absorption in Human Brain. Proceedings of the National Academy of Sciences of the United States of America, 90, 3770-3774. http://dx.doi.org/10.1073/pnas.90.8.3770
Izzetoglu, M., Bunce, S.C., Izzetoglu, K., Onaral, B. and Pourrezaei, K. (2007) Functional Brain Imaging Using Near-Infrared Technology. IEEE Engineering in Medicine and Biology Magazine, 26, 38-46. http://dx.doi.org/10.1109/MEMB.2007.384094
Van Selst, M. and Jolicoeur, P. (1994) A Solution to the Effect of Sample-Size on Outlier Elimination. The Quarterly Journal of Experimental Psychology Section A-Human Experimental Psychology, 47, 631-650. http://dx.doi.org/10.1080/14640749408401131
Cohen, J. (1988) Statistical Power Analysis for the Behavioral Sciences. 2nd Edition, Lawrence Earlbaum Associates, Hillsdale.
Boghi, A., Rampado, O., Bergui, M., Avidano, F., Manzone, C., Coriasco, M., Mortara, P., Orsi, L., Ropolo, R. and Bradac, G.B. (2006) Functional MR Study of a Motor Task and the Tower of London Task at 1.0 T. Neuroradiology, 48, 763-771. http://dx.doi.org/10.1007/s00234-006-0119-7
Newman, S.D., Carpenter, P.A., Varma, S. and Just, M.A. (2003) Frontal and Parietal Participation in Problem Solving in the Tower of London: fMRI and Computational Modeling of Planning and High-Level Perception. Neuropsychologia, 41, 1668-1682. http://dx.doi.org/10.1016/S0028-3932(03)00091-5
Ruh, N., Rahm, B., Unterrainer, J.M., Weiller, C. and Kaller, C.P. (2012) Dissociable Stages of Problem Solving (II): First Evidence for Process-Contingent Temporal Order of Activation in Dorsolateral Prefrontal Cortex. Brain and Cognition, 80, 170-176. http://dx.doi.org/10.1016/j.bandc.2012.02.012
Wagner, G., Koch, K., Reichenbach, J.R., Sauer, H. and Schlosser, R.G. (2006) The Special Involvement of the Rostrolateral Prefrontal Cortex in Planning Abilities: An Event-Related fMRI Study with the Tower of London Paradigm. Neuropsychologia, 44, 2337-2347. http://dx.doi.org/10.1016/j.neuropsychologia.2006.05.014
Moriguchi, Y. and Hiraki, K. (2013) Prefrontal Cortex and Executive Function in Young Children: A Review of NIRS Studies. Frontiers in Human Neuroscience, 7, 867. http://dx.doi.org/10.3389/fnhum.2013.00867
Tsujimoto, S. (2008) The Prefrontal Cortex: Functional Neural Development during Early Childhood. Neuroscientist, 14, 345-358. http://dx.doi.org/10.1177/1073858408316002
Barbey, A.K., Koenigs, M. and Grafman, J. (2013) Dorsolateral Prefrontal Contributions to Human Working Memory. Cortex, 49, 1195-1205. http://dx.doi.org/10.1016/j.cortex.2012.05.022
Barbey, A.K., Krueger, F. and Grafman, J. (2009) An Evolutionarily Adaptive Neural Architecture for Social Reasoning. Trends in Neurosciences, 32, 603-610. http://dx.doi.org/10.1016/j.tins.2009.09.001
Huey, E.D., Krueger, F. and Grafman, J. (2006) Representations in the Human Prefrontal Cortex. Current Directions in Psychological Science, 15, 167-171. http://dx.doi.org/10.1111/j.1467-8721.2006.00429.x
Huppert, T.J., Hoge, R.D., Diamond, S.G., Franceschini, M.A. and Boas, D.A. (2006) A Temporal Comparison of BOLD, ASL, and NIRS Hemodynamic Responses to Motor Stimuli in Adult Humans. Neuroimage, 29, 368-382. http://dx.doi.org/10.1016/j.neuroimage.2005.08.065
Strangman, G., Culver, J.P., Thompson, J.H. and Boas, D.A. (2002) A Quantitative Comparison of Simultaneous BOLD fMRI and NIRS Recordings during Functional Brain Activation. Neuroimage, 17, 719-731. http://dx.doi.org/10.1006/nimg.2002.1227
Asonitou, K., Koutsouki, D., Kourtessis, T. and Charitou, S. (2012) Motor and Cognitive Performance Differences between Children with and without Developmental Coordination Disorder (DCD). Research in Developmental Disabilities, 33, 996-1005. http://dx.doi.org/10.1016/j.ridd.2012.01.008