Effect of Dimethoate on Object Recognition Memory in Wistar Rats and Essay of Treatment with Nettle — Oak Academic Publishing
Research ArticleOpen AccessGoogle Scholar indexed
Effect of Dimethoate on Object Recognition Memory in Wistar Rats and Essay of Treatment with Nettle
Unit of Clinic and Cognitive Neuroscience, Laboratory of Biology and Health, Department of Biology, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco
,
Training and Research Unit of Biology Sciences, Peleforo Gon Coulibaly University, Korhogo, Ivory Coast
,
Unit of Clinic and Cognitive Neuroscience, Laboratory of Biology and Health, Department of Biology, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco
,
Botanical and Plant Protection Unit, Laboratory of Biology and Health, Department of Biology, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco
,
Unit of Clinic and Cognitive Neuroscience, Laboratory of Biology and Health, Department of Biology, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco
1 Unit of Clinic and Cognitive Neuroscience, Laboratory of Biology and Health, Department of Biology, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco
2 Training and Research Unit of Biology Sciences, Peleforo Gon Coulibaly University, Korhogo, Ivory Coast
3 Unit of Clinic and Cognitive Neuroscience, Laboratory of Biology and Health, Department of Biology, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco
4 Botanical and Plant Protection Unit, Laboratory of Biology and Health, Department of Biology, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco
5 Unit of Clinic and Cognitive Neuroscience, Laboratory of Biology and Health, Department of Biology, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco
Pesticides were economically important chemicals in agriculture. Their use has permitted agricultural progress, through the eradication of harmful insect and the fight against vectors of disease. However, several studies question the beneficial effects of organophosphorus compounds, showing that their deregulated use causes various problems of environmental pollution and human health. The present study shows that chronic exposure to a subtoxic dose of dimethoate is likely to affect cognitive and behavioral functions of rats (both males and females). Our results show that exposure to dimethoate affects both short and long-term memory capacities. The short-term memory results are more pronounced. Treatment with nettle extract allowed a significant improvement in cognitive and behavioral performance of the rats after their exposure to dimethoate.
Carson, R. (1963, 1994) Silent Spring. Houghton Mifflin, Boston, Massachusetts.
Costa, L.G. (2006) Current Issues in Organophosphate Toxicology. Clinica Chimica Acta, 366, 1-13. https://doi.org/10.1016/j.cca.2005.10.008
Halliwell, B. (2006) Reactive Species and Antioxidants. Redox Biology Is a Fundamental Theme of Aerobic Life. Plant Physiology, 141, 312-322. https://doi.org/10.1104/pp.106.077073
Yukti, S., Bashir, S., Irshad, M., Gupta, S.D. and Dogra, T.D. (2005) Effects of Acute Dimethoate Administration on Antioxidant Status of Liver and Brain of Experimental Rats. Toxicology, 206, 49-57. https://doi.org/10.1016/j.tox.2004.06.062
Wichtl, M. and Anton, R. (2003) Plantes thérapeutiques, tradition, pratique officinale, science et thérapeutique. [Therapeutic Plants, Tradition, Officinal Practice, Science and Therapeutics.] 2nd Edition, Inter/Tec & Doc éditions, Paris, 587-589.
Henri, C. (1997) Traité pratique et raisonné des plantes médicinales indigènes. [Practical and Rational Treaty of Native Medicinal Plants.] 3rd Edition, de l’Envol, Paris, 1251 p.
Kataki, M.S., Murugamani, V., Rajkumari, A., Mehra, P.S., Awasthi, D. and Yadav, R.S. (2012) Antioxidant, Hepatoprotective, and Anthelmintic Activities of Methanol Extract of Urtica dioica L. Leaves. Pharmaceutical Crops, 3, 38-46. https://doi.org/10.2174/2210290601203010038
Khare, V., Kushwaha, P., Verma, S., Gupta, A., Srivastava, S. and Rawat, A.K.S. (2012) Pharmacognostic Evaluation and Antioxidant Activity of Urtica dioica L. Chinese Medicine, 3, 128-135. https://doi.org/10.4236/cm.2012.33021
Pourmorad, F., Hosseinimehr, S.J. and Shahabimajd, N. (2006) Antioxidant Activity, Phenol and Flavonoid Contents of Some Selected Iranian Medicinal Plants. African Journal of Biotechnology, 5, 1142-1145.
Gulcin, I., Kufrevioglu, O.I.., Oktay, M. and Buyukokuroglu, M.E. (2004) Antioxidant, Antimicrobial, Antiulcer and Analgesic Activities of Nettle (Urtica dioica L.). Journal of Ethnopharmacology, 90, 205-215. https://doi.org/10.1016/j.jep.2003.09.028
Kanter, M., Coskun, O. and Budancamanak, M. (2005) Hepatoprotective Effects of Nigella sativa L and Urtica dioica L on Lipid Peroxidation, Antioxidant Enzyme Systems and Liver Enzymes in Carbon Tetrachloride-Treated Rats. World Journal of Gastroenterology, 11, 6684-6688. https://doi.org/10.3748/wjg.v11.i42.6684
Sarni-Manchado, P. and Cheynier, V., Eds. (2006) Les polyphénols en agroali-mentaire. [Polyphenols in Agroalimentary.] Techniques & Documentation.
Gallo, M.A. and Lawryk, N.J. (1991) Organic Phosphorus Pesticides. In: Hayes Jr., W.J. and Laws Jr., E.R., Eds., Handbook of Pesticide Toxicology, Vol. 2, Classes of Pesticides, Academic Press, San Diego, 917-1123.
Ennaceur, A. and Delacour, J. (1988) A New One-Trial Test for Neuro-biological Studies of Memory in Rats. 1: Behavioral Data. Behavioural Brain Research, 31, 47-59. https://doi.org/10.1016/0166-4328(88)90157-X
Jallouli, M., El Bini Dhouib, I., Dhouib, H., Gharbi, N. and El Fazaa, S. (2015) Effects of Dimethoate in Male Mice Reproductive Parameters. Regulatory Toxicology and Pharmacology, 73, 853-858. https://doi.org/10.1016/j.yrtph.2015.10.010
N’Go, P.K., Azzaoui, F.-Z., Soro, P.R., Samih, M., Ahami, A.O.T., Najimi, M. and Chigr, F. (2013) Developmental Effects of Malathion Exposure on Recognition Memory and Spatial Learning in Males Wistar Rats. JBBS, 3, 331-340. https://doi.org/10.4236/jbbs.2013.33033
Jones, A.L. and Karalliedde, L. (2006) Davidson’s Principles and Practice of Medicine. In: Boon, N.A., Colledge, N.R., Davidson, S.S. and Walker, B.R., Eds., 2nd Edition, Churchill Livingstone, Edinburgh, 203-226.
Eskenazi, B., Bradman, A. and Castorina, R. (1999) Exposures of Children to Organophosphate Pesticides and Their Potential Adverse Health Effects. Environmental Health Perspectives, 107, 409. https://doi.org/10.1289/ehp.99107s3409
Dibo-Cohen, C.M. (2006) Mémoire spatiale contextuelle et schizophrénie. [Contextual Spatial Memory and Schizophrenia.] Université Pierre et Marie Curie—Paris VI, Francais.
Baxter, M.G. (2009) Involvement of Medial Temporal Lobe Structures in Memory and Perception. Neuron, 61, 667-677. https://doi.org/10.1016/j.neuron.2009.02.007
Mauricio, V.-H., Castillo, I., Díaz, C., Alés, I. and Rodríguez-Moreno, A. (2012) Dimethoate Accelerates the Extinction of Eyeblink Conditioning in Mice. Neurotoxicology, 33, 105-110. https://doi.org/10.1016/j.neuro.2011.12.003
Buckmaster, C.A., Eichenbaum, H., Amaral, D.G., Suzuki, W.A. and Rapp, P.R. (2004) Entorhinal Cortex Lesions Disrupt the Relational Organization of Memory in Monkeys. Journal of Neuroscience, 24, 9811-9825. https://doi.org/10.1523/JNEUROSCI.1532-04.2004
Clarke, B.O., Porter, N.A., Marriott, P.J. and Blackbeard, J.R. (2010) Investigating the Levels and Trends of Organochlorine Pesticides and Polychlorinated Biphenyl in Sewage Sludge. Environment International, 36, 323-329. https://doi.org/10.1016/j.envint.2010.01.004
Aggleton, J.P., O’Mara, S.M., Vann, S.D., Wright, N.F., Tsanov, M. and Erichsen, J.T. (2010) Hippocampal-Anterior Thalamic Pathways for Memory: Uncovering a Network of Direct and Indirect Actions. European Journal of Neuroscience, 31, 2292-2307. https://doi.org/10.1111/j.1460-9568.2010.07251.x
Hammond, B., Dudek, R., Lemen, J. and Nemeth, M. (2004) Results of a 13 Week Safety Assurance Study with Rats Fed Grain from Glyphosate Tolerant Corn. Food and Chemical Toxicology, 42, 1003-1014. https://doi.org/10.1016/j.fct.2004.02.013
Albasser, M.M., Amin, E., Lin, T.-C.E., Iordanova, M.D. and Aggleton, J.P. (2012) Evidence That the Rat Hippocampus Has Contrasting Roles in Object Recognition Memory and Object Recency Memory. Behavioral Neuroscience, 126, 659. https://doi.org/10.1037/a0029754
Antunes, M.S., Morey, K.J., Smith, J.J., Albrecht, K.D., Bowen, T.A., Zdunek, J.K., Troupe, J.F., Cuneo, M.J., Webb, C.T., Hellinga, H.W., et al. (2011) Programmable Ligand Detection System in Plants through a Synthetic Signal Transduction Pathway. PLoS One, 6, e16292. https://doi.org/10.1371/journal.pone.0016292
Rosauro, C.J., Cammarota, M., Gruart, A., Izquierdo, I. and Delga-do-García. J.M. (2010) Plastic Modifications Induced by Object Recognition Memory Processing. Proceedings of the National Academy of Sciences, 107, 2652-2657. https://doi.org/10.1073/pnas.0915059107
Levin, D.T., Drivdahl, S.B., Momen, N. and Beck, M.R. (2002) False Predictions about the Detectability of Visual Changes: The Role of Beliefs about Attention, Memory, and the Continuity of Attended Objects in Causing Change Blindness Blindness. Consciousness and Cognition, 11, 507-527. https://doi.org/10.1016/S1053-8100(02)00020-X
Jean-Baptiste, B., Quertemont, E., Tirelli, E. and Plumier, J.-C. (2010) Anxiety in Adult Female Mice Following Perinatal Exposure to Chlorpyrifos. Neurotoxicology and Teratology, 32, 234-239. https://doi.org/10.1016/j.ntt.2009.08.008
Aldridge, J.E., Meyer, A., Seidler, F.J. and Slotkin, T.A. (2005) Alterations in Central Nervous System Serotonergic and Dopaminergic Synaptic Activity in Adulthood after Prenatal or Neonatal Chlorpyrifos Exposure. Environmental Health Perspectives, 113, 1027-1031. https://doi.org/10.1289/ehp.7968
Maryam, A., Abdollahi, M., Kebryaeezadeh, A., Hosseini, R. and Sabzevari, O. (2003) Biochemical Evidence for Free Radicalinduced Lipid Peroxidation as a Mechanism for Subchronic Toxicity of Malathion in Blood and Liver of Rats. Human & Experimental Toxicology, 22, 205-211. https://doi.org/10.1191/0960327103ht346oa
Banks, C.N. and Lein, P.J. (2012) A Review of Experimental Evidence Linking Neurotoxic Organophosphorus Compounds and Inflammation. Neurotoxicology, 33, 575-584. https://doi.org/10.1016/j.neuro.2012.02.002
Kathleen, R. and Xiong, S. (1997) Effect of Administration of Malathion for 14 Days on Macrophage Function and Mast Cell Degranulation. Toxicological Sciences, 37, 95-99. https://doi.org/10.1093/toxsci/37.1.95
Singh, A.K. and Jiang, Y. (2003) Lipopolysaccharide (lps) Induced Activation of the Immune System in Control Rats and Rats Chronically Exposed to a Low Level of the Organothiophosphate Insecticide, Acephate. Toxicology and Industrial Health, 19, 93-108. https://doi.org/10.1191/0748233703th181oa
Ferah, S. (2007) Histopathological Effects of Dimethoate on Testes of Rats. Bulletin of Environmental Contamination and Toxicology, 78, 479-484. https://doi.org/10.1007/s00128-007-9196-5
Joel, P., Bonjean, K., Cayeux, K. and Defraigne, J.-O. (2002) Mécanismes physiologiques de la défense antioxydante. [Physiological Mechanisms of Antioxidant Defense.] Nutrition clinique and métabolisme, 16, 233-239. https://doi.org/10.1016/S0985-0562(02)00166-8
Ben Amara, I., Soudani, N., Troudi, A., Bouaziz, H., Boudawara, T. and Zeghal, N. (2011) Antioxidant Effect of Vitamin E and Selenium on Hepatotoxicity Induced by Dimethoate in Female Adult Rats. Ecotoxicology and Environmental Safety, 74, 811-819. https://doi.org/10.1016/j.ecoenv.2010.11.007
Schwenke, D.C. and Behr, S.R. (1998) Vitamin E Combined with Selenium Inhibits Atherosclerosis in Hypercholesterolemic Rabbits Independently of Effects on Plasma Cholesterol Concentrations. Circulation Research, 83, 366-377. https://doi.org/10.1161/01.RES.83.4.366
Shireen, K.F., Pace, R.D., Mahboob, M. and Khan, A.T. (2008) Effects of Dietary Vitamin E, C and Soybean Oil Supplementation on Antioxidant Enzyme Activities in Liver and Muscles of Rats. Food and Chemical Toxicology, 46, 3290-3294. https://doi.org/10.1016/j.fct.2008.07.015
Ove, O.S., Eriksson, T.M., Elvander-Tottie, E., D’Addario, C., Ekstrom, J.C., Svenningsson, P., Meister, B., Kehr, J. and Stiedl, O. (2008) The Role of 5-ht 1a Receptors in Learning and Memory. Behavioural Brain Research, 195, 54-77. https://doi.org/10.1016/j.bbr.2008.02.023
Aldridge, J.E., Seidler, F.J., Meyer, A., Thillai, I. and Slotkin, T.A. (2003) Serotonergic Systems Targeted by Developmental Exposure to Chlorpyrifos: Effects during Different Critical Periods. Environmental Health Perspectives, 111, 1736. https://doi.org/10.1289/ehp.6489
Slotkin, T.A. (2002) Nicotine and the Adolescent Brain: Insights from an Animal Model. Neurotoxicology and Teratology, 24, 369-384. https://doi.org/10.1016/S0892-0362(02)00199-X
Slotkin, T.A., Lassiter, T.L., Ryde, I.T., Wrench, N., Levin, E.D. and Seidler. F.J. (2009) Consumption of a High-Fat Diet in Adulthood Ameliorates the Effects of Neonatal Parathion Exposure on Acetylcholine Systems in Rat Brain Regions. Environmental Health Perspectives, 117, 916. https://doi.org/10.1289/ehp.0800459
van Dam, P.S., Bravenboer, B., van Asbeck, B.S., Marx, J.J.M. and Gispen, W.H. (1999) High Rat Food Vitamin E Content Improves Nerve Function in Streptozotocin-Diabetic Rats. European Journal of Pharmacology, 376, 217-222. https://doi.org/10.1016/S0014-2999(99)00376-3
Mohammed, M., Shireen, K.F., Atkinson, A. and Khan, A.T. (2001) Lipid Peroxidation and Antioxidant Enzyme Activity in Different Organs of Mice Exposed to Low Level of Mercury. Journal of Environmental Science and Health, Part B, 36, 687-697. https://doi.org/10.1081/PFC-100106195